Publications

[Google Scholar]

Selected Publications:

  1. Lv, S., Kim, H., Feng, L., Song, Z., Yang, Y., Baumgartner, R., Tseng, K.-Y., Dillon, S., Leal, C., Yin, L., Cheng, J. “Unimolecular Polypeptide Micelles via Ultra-fast Polymerization of N-Carboxyanhydrides”, J. Am. Chem. Soc. 2020, 142, 19, 8570-8574.
  2. Song, Z.; Fu, H.; Baumgartner, R.; Zhu, L.; Shih, K.; Xia, Y.; Nieh, M., Chipot, C.; Lin, Y.; Cheng, J. “Enzyme-mimetic, self-catalyzed polymerization of polypeptide helices”, Nature Communications, 2019, 10, 5470.
  3. Song, Z.; Fu, H.; Wang, J.; Hui, J.; Xue, T.; Pacheco, L.A.; Yan, H.; Baumgartner, R.; Wang, Z.; Xia, Y.; Wang, X.; Yin, L.; Chen, C.; Rodríguez-Lópezd, J.; Ferguson, A.; Lin, Y.; Cheng, J. “Synthesis of polypeptides via bioinspired polymerization of in situ purified N-carboxyanhydrides”, PNAS, 2019, 116, 10658-10663
  4. Chen, C.; Fu, H.; Baumgartner, R.; Song, Z.; Lin, Y.; Cheng, J. “Proximity-Induced Cooperative Polymerization in “Hinged” Helical Polypeptides”, J. Am. Chem. Soc., 2019, 141, 8680-8693
  5. Wang, H.; Song, Z.; Lao, Y.; Xu, X.; Gong, J.; Cheng, D.; Chakraborty, S.; Park, J.S.; Li, M.; Huang, D.; Yin, L.; Cheng, J.; Leong, K.W. “Nonviral Gene Editing via CRISPR/Cas9 Delivery by Membrane-Disruptive and Endosomolytic Helical Polypeptide”, PNAS, 2018, 115, 4903-4908
  6. Lv, S. Wu, Y., Cai, K. He, H. Li, Y.; Lan, M.; Chen, X.; Cheng, J.; Yin, L. “High Drug Loading and Sub-Quantitative Loading Efficiency of Polymeric Micelles Driven by Donor-Receptor Coordination Interactions” J. Am. Chem. Soc., 2018, 140, 1235–1238
  7. Zhang, Y.; Cai, K.; Li, C.; Guo, Q.; Chen, Q.; He, X.; Liu, L.; Zhang, Y.; Lu, Y.; Chen, X.; Sun, T.; Huang, Y.; Cheng, J.; Jiang, C. “Macrophage Membrane-Coated Nanoparticles for Tumor-Targeted Chemotherapy”, Nano Lett., 2018, 18, 1908-1915
  8. Song, Z., Fu, H.; Wang, R.; Pacheco, L.; Wang, X.; Lin, Y.; Cheng, J. “Secondary structures in synthetic polypeptides from N-carboxyanhydrides: design, modulation, association, and material applications”, Chemical Society Reviews, 2018, 47, 7401-7425.
  9. Wang, H.; Wang, R.; Cai, K.; He H.; Liu, Y.; Yen, J.; Wang, Z.; Xu, M.; Sun, Y.; Zhou, X.; Yin, Q.; Tang, L.; Dobrucka, I.; Dobrucki, L.; Chaney, E.; Boppart, S.; Fan, T.; Lezmi, S.; Chen, X.; Yin, L.; Cheng, J. “Selective In Vivo Cell Labeling Mediated Cancer Targeting”, Nature Chemical Biology, 2017, 13, 415-424.
  10. Baumgartner, R., Fu, H.; Song, Z.; Lin, Y.; Cheng, J. “Cooperative polymerization of α-helices induced by macromolecular architecture”, Nature Chemistry, 2017, 9, 614–622
  11. Xiong M.; Bao Y.; Xu, X.; Wang, H.; Han, Z.; Wang, Z.; Liu, Y.; Huang, S.; Song. Z; Chen, J.; Peek, R.M. Jr., Yin, L.; Chen, L.; Cheng, J. “Selective Killing of Helicobacter pylori with pH-Responsive Helix-Coil Conformation Transitionable Antimicrobial Polypeptides”. PNAS, 2017, 114, 12675-12680
  12. Song, Z.; Mansbach, RA; He, H.; Shik, KC; Baumgartner, R.; Zheng, N.; Ba, X.; Huang, Y.; Mani, D.; Nieh, MP; Ferguson, AL; Yin, L.; Cheng, J. “Modulation of Polypeptide Conformation through Donor-Acceptor Transformation of Side-Chain Hydrogen Bonding Ligands”, Nature Communications., 2017, 8, 92
  13. Song, Z.; Han, Z.; Lv, S.; Chen, C.; Chen, L.; Lin, Y.; Cheng, J. “Synthetic polypeptides: from polymer design to supramolecular assembly and biomedical application”. Chemical Society Reviews, 2017, 46, 6570-6599
  14. Xiong, M.; Han, Z.; Song, Z.; Yu, J.; Ying, H.; Yin, L; Cheng, J. “Bacteria-Assisted Activation of Antimicrobial Polypeptides via Random Coil-to-Helix Transition”, Angew Chem. Int. Ed., 2017, 56, 10826-10829
  15. Xia, H.; Fu, H.; Zhang, Y.; Shih, K.; Ren, Y.; Anuganti, M.; Nieh, M; Cheng, J.; Lin, Y. “Supramolecular Assembly of Comb-like Macromolecules Induced by Chemical Reactions that Modulate the Macromolecular Interactions in-situ”, J. Am. Chem. Soc., 2017, 139, 11106–11116
  16. Chen, J.; Ding, J.; Wang, Y.; Cheng, J.; Ji, S.; Zhuang, X.; Chen, X. “Sequentially Responsive Shell-Stacked Nanoparticles for Deep Penetration into Solid Tumors”, Advanced Materials, 2017, 29, 201701170
  17. Lee, MW; Han, M.; Bossa GW;  Snell, C.; Song, Z.; Tang T.; Yin, L.; Cheng, J.; May, S.; Luijten, E.; Wong, GCL “Interactions between Membranes and “Metaphilic” Polypeptide Architectures with Diverse Side-Chain Populations”, ACS Nano, 2017, 11, 2858-2871.
  18. Bao, Y.; Wu, X.; Chen, J.; Hu, X.; Zeng, F.; Cheng, J.; Jin, H. Lin, X.; Chen, L. “Brd4 modulates the innate immune response through Mnk2-eIF4E pathway-dependent translational control of IκBα”. PNAS, 2017, 114(20): E3993-E4001.
  19. Wang, H.; Gauthier, M.; Kelly, J. R.; Miller, R.J.; Xu, M.; O’Brien, W.D.; Cheng, J. “Targeted Ultrasound Assisted Cancer-Selective Chemical Labeling and Subsequent Cancer Imaging via Click Chemistry”, Angew Chem. Int. Ed. 2016, 55, 5452-5456
  20. Wang, R.; Xu, Y.; Zhang, J.; Cheng, J. Tong, R. “β-Diiminate Zinc Catalyst for Controlled Ring-Opening Polymeriza-tion of O-Carboxyanhydrides”, Angew Chem. Int. Ed., 2016, 55, 13010-130114
  21. Yin, Q.; Tang, L.; Cai, K.; Tong, R.; Sternberg, R.; Yang, X.; Dobrucki, L.W.; Borst, L.B.; Kamstock, D.; Song, Z.; Helferich, W.G.; Cheng, J.; Fan, T.M. “Pamidronate Functionalized Nanoconjugates for Targeted Therapy of Focal Skeletal Malignant Osteolysis”, PNAS, 2016. 113, E4601-E4609.
  22. Zhang, Y.; Ying, H.; Hart, K.R.; Wu, Y.; Hsu, A.J.; Coppola, A.M.; Kim, T.A.; Yang, K.; Sottos, N.R.; White, S.R.; Cheng, J. “Malleable and Recyclable Poly(urea-urethane) Thermoset Bearing Hindered Urea Bonds”,Advanced Materials, 2016, 28, 7646-7651
  23. Bai, Y.; Nguyen, L.T.; Song, Z.; Peng, S.; Lee, J.; Zheng, N.; Kapoor, I.; Lauren D. Hagler, L.; Cai, K.; Cheng, J.; Chan, H.Y.; Zimmerman, S.C. “Integrating Display and Delivery Functionality with a Cell Penetrating Peptide Mimic as a Scaffold for Intracellular Multivalent Multi-targeting”,  J. Am. Chem. Soc., 2016, 138, 9498-9507.
  24. He, H.; Zheng, N.; Song, Z.; Kim, K.H.; Yao, C.; Zhang, R.; Zhang, C.; Huang, Y.; Uckun, F.M.; Cheng, J.; Zhang, Y.; Yin, L. “Suppression of Hepatic Inflammation viaSystemic siRNA Delivery by Membrane-Disruptive and Endosomolytic Helical Polypeptide Hybrid Nanoparticles”, ACS NANO, 2016, 10, 1859-1870.
  25. Kang, S.; Murphy, R.; Hwang, S.; Lee, S.; Harburg, D.; Krueger, N.; Shin, J.; Gamble, P.; Cheng,H.; Yu, S.; Liu, Z.; McCall, J.; Stephen, M.; Ying, H.; Kim, J.; Park, G.; Webb, R.; Lee, C.; Chung, S.; Wie, D.; Gujar, A.; Cheng, J.; Huang, Y.; Lee, S.; Braun, P.; Ray, W.; Rogers, J.A. ” Bioresorbable Silicon Electronic Sensors for the Brain”, Nature, 2016, 530, 71–76
  26. Xiong, M.; Lee, MW; Song, Z.; Yao, C.; Wong, GCL; Cheng J. “Helical Antimicrobial Polypeptides with Radial Amphiphilicity”, PNAS, 2015, 112, 13155–13160.
  27. Torabi, S.F.; Wu, P.; McGhee, C.E.; Chen, L.; Hwang, K.; Zheng, N.; Cheng, J.; Lu, Y. “In vitro selection of a sodium-specific DNAzyme and its application in intracellular sensing”, PNAS, 2015, 112, 5903-5908.
  28. Cai, K.; He, X.; Song, Z.; Yin, Q.; Zhang, Y.; Uckun, F.M.; Jiang, C.; Cheng, J. “Dimeric Drug Polymeric Nanoparticles with Exceptionally High Drug Loading and Quantitative Loading Efficiency”, J. Am. Chem. Soc., 2015, 137, 3458-3461.
  29. Priftis, D.; Leon, L.; Song, Z.; Perry, S.; Margossian, K.; Tropnikova, A.; Cheng, J.; Tirrell, M. “Self-assembly of α-helical polypeptides driven by complex coacervation”, Angew Chem. Int. Ed., 2015, 14, 11128–11132.
  30. Tang, L.; Tong, T.; Coyle, VJ; Pondenis, H.; Borst, LB; Cheng, J.; Fan, TM. “Targeting Tumor Vasculature with Aptamer Functionalized Doxorubicin-Polylactide Nanoconjugates for Enhanced Cancer Therapy”, ACS Nano, 2015, 9, 5072-5081.
  31. Wu, X.; He, C.; Wu, Y.; Chen, X.; Cheng, J. “Nanogel-Incorporated Physical and Chemical Hybrid Gels for Highly Effective Chemo-Protein Combination Therapy”, Adv. Func. Mat. 2015, 25, 6744-6755.
  32. Qu, Q.; Dong, L.; Louis, K.R.; Li, X.; Yang, H.; Sun, Q.; Crandall, S.R.; Tsang, S.; Zhou, J.; Cox, C.L.; Cheng, J.; Wang, F. “High-efficiency motor neuron differentiation from human pluripotent stem cells and the function of Islet-1”, Nature Communications, 2014, 5, 3449.
  33. Ying, H.; Zhang, Y.; Cheng, J. “Dynamic urea bond for the design of reversible and self-healing polymers”, Nature Communications, 2014, 5, 3218.
  34. Tang, L.; Yang, X.; Yin, Q.; Cai, K.; Wang, H.; Chaudhury, I.; Yao, C.; Zhou, Q.; Kwon, M.; Hartman, J.A.; Dobrucki, I.T.; Dobrucki, L.W.; Borst,. L.B.; Lezmi, S.; Helferich, W.G.; Ferguson, A.L.; Fan, T.M.; Cheng, J. “Investigating the optimal size of anticancer nanomedicine”, PNAS, 2014, 111, 15344-15349.
  35. Ying H.; Cheng, J. “Hydrolysable Polyureas Bearing Hindered Urea Bonds”,  J. Am. Chem. Soc., 2014, 36, 16974-16977.
  36. Yin, L.; Huang, X.; Xu, H.; Zhang, Y.; Lam, J.; Cheng, J.; Rogers, JA. “Materials, Designs, and Operational Characteristics for Fully Biodegradable Primary Batteries”, Advanced Materials, 2014, 23, 3879-3884.
  37. Tong, R.; Tang, L.; Ma, L.; Tu, C.; Baumgartner, R.; Cheng, J. “Smart Chemistry in Polymeric Nanomedicines,” Chemical Society Reviews,. 2014,43, 6982-7012.
  38. Zhang, Y.; Yin, Q.; Yin, L.; Ma, L.; Tang, L.; Cheng, J. “Chain-Shattering Polymeric Therapeutics with On-Demand Drug-Release Capability”, Angew Chem. Int. Ed. 2013, 52, 6435-6439.
  39. Yin, L.; Song, Z.; Qu, Q.; Kim, KH; Zheng, N.; Yao, C.; Chaudhury, I.; Tang, H.; Gabrielson, NP; Uckun, F.M.; Cheng, J. “Supramolecular self-assembled nanoparticles mediate oral delivery of therapeutic TNF-α siRNA against systemic inflammation”, Angew Chem. Int. Ed. 2013, 52, 5757-5761.
  40. Yin, L.; Tang, H.; Kim, KH.; Zheng, N.; Song, Z.; Gabrielson, NP.; Lu, H.; Cheng, J. “Light-Responsive Helical Polypeptides Capable of Reducing Toxicity and Unpacking DNA: Toward Nonviral Gene Delivery”, Angew Chem. Int. Ed., 2013, 52, 9182-9186.
  41. Yin, Q.; Yap, F.Y.; Yin, L.; Ma, L.; Zhou, Q.; Dobrucki, L.W.; Fan, T.M.; Gaba, R.C.; Cheng, J. “Poly(iohexol) Nanoparticles As Constrast Agents for In Vivo X-ray Computed Tomography Imaging”,  J. Am. Chem. Soc., 2013, 135, 13620-13623.
  42. Wang, J.; Xia, H.; Zhang, Y.; Lu, H.; Kamat, R.; Dobrynin, A.; Cheng, J.; Lin, Y. “Nucleation-Controlled Polymerization of Nanoparticles into Supramolecular Structures”, J. Am. Chem. Soc., 2103, 135, 11417-11420.
  43. Yin, L.; Song, Z.; Kim, KH; Zheng, N.; Gabrielson, NP; Cheng, J. “Non-Viral Gene Delivery Based on Supramolecular Self-Assembled Nanocomplexes via Membrane Penetration and Mannose Targeting“, Advanced Materials, 2013, 25, 3063-3070.
  44. Tang, L.; Cheng, J. “Nonporous Silica Nanoparticles for Nanomedicine Application”, Nano Today, 2013,8, 290-312.
  45. Tang, L.; Yang, X.; Dobrucki, L.W.; Chaudhury, I.; Yin, Q.; Yao, C.; Lezmi, S.; Helferich, WG Fan, TM; Cheng, J.  “Aptamer-functionalized, ultra-small, monodisperse silica nanoconjugate for targeted dual-modal imaging of lymph nodes with metastatic tumors“, Angew Chem. Int. Ed., 2012, 124, 12893 -12898.
  46. Gabrielson, N.; Lu, H.; Yin, L.; Li, D.; Wang, F.; Cheng, J.; “Reactive and Bioactive Cationic g-Helical Polypeptide Template for Non-Viral Gene Delivery”, Angew Chem. Int. Ed., 2012, 51, 1143-1147.
  47. Tang, L.; Fan, TM.; Borst, LB; Cheng, J. “Synthesis and biological response of size-specific, monodisperse drug-silica nanoconjugates”, ACS Nano., 2012, 6, 3954-3966.
  48. Lu, H.; Wang, J.; Bai, Y.; Lang, J. Liu, S. Lin, Y.; Cheng, J. “Ionic Polypeptides with Unusual Helical Stability”, Nature Communications, 2011, 2, 206.
  49. Mishra, A.; Lai, GH; Schmidt, NW; Sun, VZ; Rodriguez, AR, Tong, R.; Tang, L.; Cheng, J.; Deming, TJ;  Kamei, DT; Wong, GCL. “Translocation of HIV TAT peptide and analogues induced by multiplexed membrane and cytoskeletal interactions”, PNAS, 2011, 108, 16883-16888.
  50. Wang, J.; Lu, H.; Kamat, R.; Pingali, S. V.; Urban, V. S.; Cheng, J.; Lin, Y. “Supramolecular Polymerization from Polypeptide-Grafted Comb Polymers”, J. Am. Chem. Soc., 2011, 133, 12906-12909.
  51. Chan, J.; Zhang, L. F.; Tong, R.; Ghosh, D.; Gao, W.; Liao, G.; Yuet, K.; Gray, D.; Rhee, J. W.; Cheng, J.; Golomb, G.; Libby, P; Langer, R.; Farokhzad, O. “Spatiotemporal Controlled Delivery of Nanoparticles to Injured Vasculature”, PNAS, 2010, 107, 2213-2218.
  52. Li, C.; Zhang, Y.; Hu, J..; Cheng, J.; Liu, S. “Reversible Three-State Switching of Multicolor Fluorescence Emission via Multiple Stimuli-Modulated FRET Processes within Thermoresponsive Polymeric Micelles”, Angew Chem. Int. Ed., 2010, 49, 5120-5124.
  53. Lu, H.; Wang, J.; Lin, Y.; Cheng, J. “One-Pot Synthesis of Brush-Like Polymers via Integrated Ring-Opening Metathesis Polymerization and Polymerization of Amino Acid N-Carboxyanhydrides”,  J. Am. Chem. Soc., 2009, 131, 13582-13583.
  54. Cao, Z.; Tong, R.; Xu, W.; Wong, GWL.; Cheng, J.; Lu, Y. “Reversible cell-specific delivery of chemotherapy drugs using aptamer-functionalized liposomes”, Angew Chem. Int. Ed.,, 2009, 48, 6494-6498.
  55. Tong, R.; Cheng, J. “Ring-Opening Polymerization Mediated-Controlled Formulation of Polylactide Nanoparticles”, J. Am. Chem. Soc., 2009, 131, 4744-4754.
  56. Lu, H.; Cheng, J.  “Controlled Ring-Opening Polymerization of Amino Acid N-Carboxyanhydrides and Facile End Group Functionalization of Polypeptides”, J. Am. Chem. Soc., 2008, 130, 12562-12563.
  57. Tong, R.; Cheng, J. “Paclitaxel-Initiated, Controlled Polymerization of Lactide for the Formulation of Polymeric Nanoparticulate Delivery Vehicles”, Angew Chem. Int. Ed.,, 2008, 47, 4830-4834.
  58. Lu, H.; Cheng, J. “Hexamethyldisilazane-Mediated Controlled Polymerization of α-Amino Acid-NCarboxyanhydrides”, J. Am. Chem. Soc., 2007, 129, 14114-14115.
  59. Farokhzad, OC; Cheng J. (co-first author), Teply, B.A.; Sherifi I.; Khademhosseini A.; Langer, R. “In vivo prostate tumor reduction after single administration of docetaxel encapsulated nanoparticle-aptamer bioconjugates”, PNAS, 2006, 103, 6315-6320.

 

Complete List

2021

208. Yang, Y., Ying, H., Li, Z., Wang, J., Ferguson, A., Zhang, Y., Cheng, J. “Near quantitative synthesis of urea macrocycles enabled by bulky N-substituent”, Nature Communications 2021, 12, 1572. [PDF][SI][Link]

207. Jiang, Y., Chen, Y., Song, Z., Tan, Z., Cheng, J. “Recent advances in design of antimicrobial peptides and polypeptides toward clinical translation”, Advanced Drug Delivery Reviews 2021, 170, 261-280. (NSF-CHE1709820) [PDF][Link]

206. Xia, Y., Song, Z., Tan, Z., Xue, T. Wei, S., Zhu, L., Yang, Y., Fu, H., Jiang, Y., Lin, Y., Lu, Y., Ferguson, A.L., Cheng, J. “Accelerated polymerizaton of N-carboxyanhydrides catalyzed by crown ether”, Nat Commun 2021, 12, 372. (NSF-CHE-1709820) [PDF][SI][Link]

2020

205. Jiang, Y., Han, M., Bo, Y., Feng, Y., Li, W., Wu, J.R., Song, Z., Zhao, Z., Tan, Z., Chen, Y., Xue, T., Fu, Z., Kuo, S.H., Lau, G.W., Lujiten, E., Cheng, J. ““Metaphilic” Cell-Penetrating Polypeptide-Vancomycin Conjugate Efficiently Eradicates Intracellular Bacteria via a Dual Mechanism”,  ACS central science. 2020, 6, 12, 2267–2276 (NSF-CHE-1709820, NIH-1R01CA207584) [PDF][SI][Link]

204. Song, Z., Khaw, Y. M., Pacheco, L. A., Tseng, K.-Y., Tan, Z., Cai, K., Ponnusamy, E., Cheng, J.*, Inoue, M.* “Induction of a higher-ordered architecture in glatiramer acetate improves its biological efficiency in a multiple sclerosis animal model”, Biomater. Sci. 2020, 8, 5271. (NSF-CHE-1709820) [PDF] [SI] [Link]

203.  Song, Z., Chen, X., Wang, Z., King, S., Yan, H., Cai, K., Cheng, J., “Potential bleach activators with improved imide hydrolytic stability”, International Journal of Industrial Chemistry, 2020, 11, 177-185. (Dow) [Link]

202. Wang, S., Yang, Y., Ying, H., Jing, X., Wang, B., Zhang, Y., Cheng, J. “Recyclable, Self-Healable, and Highly Malleable Poly(urethane-urea)s with Improved Thermal and Mechanical Performances”, ACS Appl. Mater. Interfaces, 2020, 12, 31 35403-35414. [PDF][SI][Link]

201.  Xue, T., Song, Z., Wang, Y., Zhu, B., Zhao, Z., Tan, Z., Wang, X., Xia, Y., Cheng, J. “Streamlined synthesis of PEG-polypeptides directly from amino acids”, Macromolecules, 2020, 53, 15, 6589-6597. (NSF-CHE 1709820) [PDF][SI][Link]

200.  Shen, L., Cai, K., Yu, J., Cheng, J. “Facile Click-Mediated Cell Imaging Strategy of Liposomal Azido Mannosamine Lipids via Metabolic or Nonmetabolic Glycoengineering”, ACS Omega, 2020, 5, 23, 14111-14115.  (NIH-1R01EB02565101)[PDF][SI][Link]

199.  Lv, S., Kim, H., Feng, L., Song, Z., Yang, Y., Baumgartner, R., Tseng, K.-Y., Dillon, S., Leal, C., Yin, L., Cheng, J. “Unimolecular Polypeptide Micelles via Ultra-fast Polymerization of N-Carboxyanhydrides”, J. Am. Chem. Soc. 2020, 142, 19, 8570-8574. (NSF-CHE 1709820) [PDF] [SI] [Link]

198.  Bo, Y., Jiang, Y., Chen, K., Cai, K., Li, W., Roy, J., Bao, Y., Cheng, J. “Targeting Infected Host Cells in vivo via Responsive Azido-Sugar Mediated Metabolic Cell Labeling Followed by Click Reaction”, Biomaterials, 2020, 238, 119843 (NIH-1R01EB025651) [PDF] [SI] [Link]

197.  Song, Z., Tan, Z., Zheng, X., Fu, Z., Ponnusamy, E., Cheng, J. “Manipulating the helix-coil transition profile of synthetic polypeptides through leveraging side-chain molecular interactions”, Polym. Chem., 2020, 11, 1445-1449. (NSF-CHE 1709820) [PDF] [SI] [Link]

2019

196.  Song, Z., Fu, H., Baumgartner, R., Zhu, L., Shih, K.-C., Xia, Y., Zheng, X., Yin, L., Chipot, C., Lin, Y., Cheng, J. “Enzyme-mimetic self-catalyzed polymerization of polypeptide helices” Nature Communications, 2019, 10, 5470. (NSF-CHE-1709820) [PDF] [Link]

195. Song, Z., Fu, H., Wang, J., Hui, J., Xue, T., Pacheco, L.A., Yan, H., Baumgartner, R., Wang, Z., Xia, Y., Wang, X., Yin, L., Chen. C., Roderiguez-Lopez. J., Ferguson. A., Lin. Y., Cheng. J.”Synthesis of polypeptides via bioinspired polymerization of in situ purified N-carboxyanhydrides”, PNAS,

194. Chen, C.; Fu, H.; Baumgartner, R.; Song, Z.; Lin, Y.; Cheng, J. “Proximity-Induced Cooperative Polymerization in “Hinged” Helical Polypeptides“, J. Am. Chem. Soc., 2019, 141, 22, 8680-8693. (NSF-CHE-1709820; NSF-CHE-1410581; NSF-DMR-1809497 and NNSF- No.21404062).  [PDF[Link]

193.  Wang, X., Song, Z., Tan, Z., Zhu, L., Xue, T., Lv, S., Fu, Z., Zheng, X., Ren, J., Cheng, J. “Facile Synthesis of Helical Multiblock Copolypeptides: Minimal Side Reactions with Accelerated Polymerization of N‑Carboxyanhydrides” ACS Macro Lett., 2019, 8, 1517−1521. (NSF-CHE-1709820, NIH-1R01CA207584) [PDF] [SI] [Link]

192. Chen, X.; Zheng, G.; Cheng, J.; Yang, Y. “Supramolecular Nanotheranostics”, Theranostics, 2019, 9, 3014-3016 [PDF][Link]

191. Ying, H.; Yang, Y.; Cai, K.; Cheng, J. “Hindered Urea Bond: A Bilaterally Responsive Chemistry to Hydrogen Peroxide”, European Journal of Organic Chemistry 2019, 4, 728-731 (NSF-CHE 17-09820) [PDF][Link]

190. Wang, H., Liu, Y., Xu, M., Cheng, J. “Azido-Galactose Outperforms Azido-Mannose for Metabolic Labeling and Targeting of Hepatocellular Carcinoma” Biomater. Sci., 2019, 7, 4166-4173.  (NIH-R01-EB025651)[PDF][SI][Link]

189. Shen, L., Cai, K., Yu, J.,  Cheng, J. “Novel Liposomal Azido Mannosamine Lipids on Metabolic Cell Labelling and Imaging via Cu-free Click Chemistry.”  Bioconjugate Chem, 2019, 30, 9, 2317-2322. (NIH-1R01EB02565101, NIH- 1R01CA207584) [PDF][SI][Link]

188. Wang, H., Bo, Y., Liu, Y., Xu. M., Cai. K., Wang. R., Cheng, J., “In Vivo Cancer Targeting via Glycopolyester Nanoparticle Mediated Metabolic Cell Labeling Followed by Click Reaction”  Biomaterials, 2019, 119305. (NIH-1DP2OD007246, NSF-DMR-1309525) [PDF][SI][Link]

187. Song, Z., Tan, Z., Cheng, J., “Recent Advances and Future Perspectives of Synthetic Polypeptides from N‑Carboxyanhydrides” Macromolecules, 2019, 52, 8521-8539. (NSF-CHE-1709820) [PDF] [Link]

186.  Jia, Y.; Ying, H.; Zhang, Y.; He, H.; Cheng, J. “Reconfigurable Poly (urea-urethane) Thermoset Based on Hindered Urea Bonds with Triple-shape Memory Performance”,  Macromol. Chem. Phys., 2019, 1900148 (NSF-CHE-1508710)[PDF] [SI[Link]

185. Mei, Y., Wang, R., Jiang, W., Bo, Y., Zhang, T., Yu, J., Cheng, M., Wu, Y., Cheng, J., Ma, W.,”Recent progress in nanomaterials for nucleic acid delivery in cancer immunotherapy” Biomater. Sci., 2019, 7, 2640-2651. [PDF][Link]

2018

184.Wang, H.; Song, Z.; Lao, Y.; Xu, X.; Gong, J.; Cheng, D.; Chakraborty, S.; Park, J.S.; Li, M.; Huang, D.; Yin, L.; Cheng, J.; Leong, K.W. “Nonviral Gene Editing via CRISPR/Cas9 Delivery by Membrane-Disruptive and Endosomolytic Helical Polypeptide “, PNAS, (NIH-HL109442; NIH-AI096305; NIH-GM110494; NIH-UH3 TR000505) [PDF] [SI] [Link]

183. Song, Z.; Fu, H.; Wang, R.; Pacheco, L.A.; Wang, X.; Lin, Y.; Cheng, J. “Secondary structures in synthetic polypeptides from N-carboxyanhydrides: design, modulation, association, and material applications”, Chem. Soc. Rev., 2018, 47, 7401-7425. (NSF-CHE-1709820; NSF-CHE-1308485 ) [PDF] [Link]

182. Lv, S.; Wu, Y.; Cai, K.; He, H.; Li, Y.; Lan, M.; Chen, x.; Cheng, J.; Yin, L. “High Drug Loading and Sub-Quantitative Loading Efficiency of Polymeric Micelles Driven by Donor-Receptor Coordination Interactions”, J. Am. Chem. Soc., 2018, 140, 1235–1238. [PDF][SI][Link]

181. Zhang, Y.; Cai, K.; Li, C.;  Guo, Q.; Chen, Q.; He, X.; Liu, L.; Zhang, Y.; Lu, Y.; Chen, X.; Sun, T.; Huang, Y.; Cheng, J.; Jiang, C. “Macrophage-Membrane-Coated Nanoparticles for Tumor-Targeted Chemotherapy”, Nano Lett.201818, 1908–1915. (NSF-Grant 81425023; NSF-DMR-1309525 ; NIH-R01 1R01CA207584 and R21 CA198684)  [PDF] [SI] [Link]

180. He, H.; Chen, Y.; Li, Y.; Song, Z.; Zhong, Y.; Zhu, R.; Cheng, J.; Yin, L. “Effective and Selective Anti-Cancer Protein Delivery via All-Function-in-One Nanocarriers Coupled with Visible Light-Responsive, Reversible Protein Engineering”, Adv. Funct. Mater., 2018, DOI: 10.1002/adfm.201706710. [PDF][SI][Link]

179. He, X.; Zhang, J.; Li, C.; Zhang, Y.; Lu, Y.; Zhang, Y.; Liu, L.; Ruan, C.; Chen, Q.; Chen, X.; Guo, X.; Sun, T.; Cheng, J.; Jiang, C. “Enhanced bioreduction-responsive diselenide-based dimeric prodrug nanoparticles for triple negative breast cancer therapy”, Theranostics, 2018, 8, 4884

178. He, X.; Cai, K.; Zhang, Y.; Lu, Y.; Guo, Q.; Zhang, Y.; Liu, L.; Ruan, C.; Chen, Q.; Chen, X.; Li, C.; Sun, T.; Cheng, J.; Jiang, C. “Dimeric Prodrug Self-Delivery Nanoparticles with Enhanced Drug Loading and Bioreduction Responsiveness for Targeted Cancer Therapy”, ACS applied materials & interfaces, 2018, 10, 39455-39467

177. Ying, H.;  Yang, Y.; Cai, K.; Cheng, J. “Hindered Urea Bond: A Bilaterally Responsive Chemistry to Hydrogen Peroxide”, Eur. J. Org. Chem., 2019, 728-731. (NSF CHE 17-09820; American ChemicalSociety Petroleum Research Fund (58671-ND7)). [PDF] [SI[Link]

176. Liu, L.; Wang, R.; Wang, C.; Wang, J.;  Chen, L.; Cheng, J. “Light-triggered release of drug conjugates for an efficient combination of chemotherapy and photodynamic therapy”, Biomater. Sci., 2018,6, 997-1001. [PDF] [SI] [Link]

175. Liu, Y.; Song, Z.; Zheng, N.; Nagasaka, K.; Yin, L.; Cheng, J. “Systemic siRNA delivery to tumors by cell-penetrating α-helical polypeptide-based metastable nanoparticles”, Nanoscale, 2018, 10, 15339–15349. (NSF-CHE 1709820; NIH-1R01CA207584) [PDF] [SI] [Link]

174. Wan, J.; Sun, L.; Wu, P.; Wang, F.; Guo, J.; Cheng, J.; Wang, C. “Light-triggered release of drug conjugates for an efficient combination of chemotherapy and photodynamic therapy”, Biomaterials Science, 2018, 6, 997-1001

173. Cai, K.; Ying, H.; Cheng, J. “Dynamic Ureas with Fast and pH-independent Hydrolytic Kinetics”, Chem. Eur. J., 2018, 24, 7345 –7348. (NSF-CHE15‐08710) [PDF] [SI] [Link]

172. Wang, R.; Cai, K.; Wang, H.; Yin, C.;  Cheng, J. “A caged metabolic precursor for DT-diaphorase responsive cell labeling”, Chem.Comm., 2018, 54, 4878–4881. (NIH-R21 1R21CA198684; NIH-1R01CA207584) [PDF] [Link]

171. Wan, J.; Sun, L.; Wu, P.; Wang, F.; Guo, J.; Cheng, J.; Wang, C. “Synthesis of indocyanine green functionalized comblike poly (aspartic acid) derivatives for enhanced cancer cell ablation by targeting the endoplasmic reticulum”, Polymer Chemistry, 2018, 9, 1206-1215. [PDF] [SI] [Link]

170. Yin, Q.; Tang, L.; Cai, K.; Yang, X.; Yin, L.; Zhang, Y.; Dobrucki, L.W.; Helferich, W.G.; Fan, T.M.; Cheng, J. “Albumin as a “Trojan Horse” for Polymeric Nanoconjugates Transendothelial Transport across Tumor Vasculatures for Improved Cancer Targeting”, Biomater. Sci., 2018, 6, 1189–1200. (NIH-1R01CA207584 ; NIH-1R21CA198684) [PDF] [SI] [Link]

2017

169. Wang, H.; Wang, R.; Cai, K.; He, H.; Liu, Y.; Yen, J.; Wang, Z.; Xu, M.; Sun, Y.; Zhou, X.; Yin, Q.; Tang, L.; Dobrucka, I.; Dobrucki, L.; Chaney, E.; Boppart, S.; Fan, T.; Lezmi, S.; Chen, X.; Yin, L.; Cheng, J. “Selective In Vivo Cell Labeling Mediated Cancer Targeting”, Nature Chemical Biology, 2017, 13, 415-424. (NIH-1DP2OD007246; NSF-DMR1309525) [PDF] [SI] [Link]

168. Baumgartner, R., Fu, H.; Song, Z.; Lin, Y.; Cheng, J. “Cooperative polymerization of α-helices induced by macromolecular architecture”, Nature Chemistry, 2017, 9, 614–622. (NSF-CHE1308485; NSF-CHE1508710) [PDF] [SI] [Link]

167. Xiong, M.; Bao, Y.; Xu, X.; Wang, H.; Han, Z.; Wang, Z.; Liu, Y.; Huang, S.; Song, Z; Chen, J.; Peek, R.M. Jr., Yin, L.; Chen, L.; Cheng, J. “Selective Killing of Helicobacter pylori with pH-Responsive Helix-Coil Conformation Transitionable Antimicrobial Polypeptides”,  [PDF][SI][Link]

166. Song, Z.; Mansbach, R.A.; He, H.; Shik, K.C.; Baumgartner, R.; Zheng, N.; Ba, X.; Huang, Y.; Mani, D.; Nieh, M.P.; Ferguson, A.L.; Yin, L.; Cheng, J. “Modulation of Polypeptide Conformation through Donor-Acceptor Transformation of Side-Chain Hydrogen Bonding Ligands”, Nature Commun., 2017, 8, 92. (NSF-CHE1308485; NSF-CBET1510468) [PDF] [SI] [Link]

165. Song, Z.; Han, Z.; Lv, S.; Chen, C.; Chen, L.; Lin, Y.; Cheng, J. “Synthetic polypeptides: from polymer design to supramolecular assembly and biomedical application”, Chem. Soc. Rev., 2017, 46, 6570-6599. (NSF-CHE1308485) [PDF] [Link]

164. Xiong, M.; Han, Z.; Song, Z.; Yu, J.; Ying, H.; Yin, L; Cheng, J. “Bacteria-Assisted Activation of Antimicrobial Polypeptides via Random Coil-to-Helix Transition”, Angew. Chem. Int. Ed., 2017, 56, 10826 –10829. (NSF-CHE1153122; NIH-1DP2OD007246; NIH-1R21EB013379) [PDF] [SI] [Link]

163. Xia, H.; Fu, H.; Zhang, Y.; Shih, K.; Ren, Y.; Anuganti, M.; Nieh, M; Cheng, J.; Lin, Y. “Supramolecular Assembly of Comb-like Macromolecules Induced by Chemical Reactions that Modulate the Macromolecular Interactions in-situ”, J. Am. Chem. Soc., 2017, 139, 11106-11116. (NSF-DMR1150742; NSF-CHE1410581; NSF-CHE1308485) [PDF] [SI] [Link]

162. Chen, J.; Ding, J.; Wang, Y.; Cheng, J.; Ji, S.; Zhuang, X.; Chen, X. “Sequentially Responsive Shell-Stacked Nanoparticles for Deep Penetration into Solid Tumors”, Advanced Materials, 2017, 29DOI: 10.1002/adma.201701170. [PDF] [SI] [Link]

161. Lee, M.W.; Han, M.; Bossa, G.W.; Snell, C.; Song, Z.; Tang, T.; Yin, L.; Cheng, J.; May, S.; Luijten, E.; Wong, GC.L. “Interactions between Membranes and “Metaphilic” Polypeptide Architectures with Diverse Side-Chain Populations”, ACS Nano, 2017, 11, 2858-2871. (NSF-DMR1309525; NIH-1R21AI117080) [PDF] [SI] [Link]

160. Ying, H.; Yen, J.; Wang, R.; Lai, Y.; Hu, Y.; Cheng, J. “Degradable and biocompatible hydrogels bearing a hindered urea bond”, Biomater. Sci., 2017, 5, 2398–2402. (NSF-CHE15-08710) [PDF][Link]

159. Zheng, N.; Song, Z.; Yang, J.; Liu, Y.; Li, F.; Cheng, J.; Yin, L. “Manipulating the membrane penetration mechanism of helical polypeptides via aromatic modification for efficient gene delivery”, Acta Biomaterialia., 2017, 58, 146–157. (NSF-CHE1153122; NIH-1DP2OD007246; NIH-1R21EB013379) [PDF][SI][Link]

158. Ren, Y.; Baumgartner, R.; Fu, H.; Schoot, P.V.D.; Cheng, J.; Lin, Y. “Revisiting the Helical Cooperativity of Synthetic Polypeptides in Solution”, Biomacromolecules, 2017, 18, 2324-2332. (NSF-DMR1150742; NSF-CHE1410581; NSF-CHE1308485) [PDF] [SI] [Link]

157. Bao, Y.; Wu, X.; Chen, J.; Hu, X.; Zeng, F.; Cheng, J.; Jin, H. Lin, X.; Chen, L. “Brd4 modulates the innate immune response through Mnk2-eIF4E pathway-dependent translational control of IκBα”,  PNAS, 2017, 114, 3993-4001. [PDF] [SI] [Link]

156. Baumgartner, R.; Kuai, D.; Cheng, J. “Synthesis of controlled, high-molecular weight poly(L-glutamic acid) brush polymers”, Biomater. Sci., 2017, 5, 1836–1844. (NSF-DMR1309525; NIH-1R21AI117080) [PDF] [SI] [Link]

155. Ren, Y.; Fu, H.; Baumgartner, R.; Zhang, Y.; Cheng, J.; Lin, Y. “Folding Cooperativity of Synthetic Polypeptides with or without “Tertiary” Interactions”, ACS Macro Letter, 2017, 6, 733-737. (NSF-CHE1308485) [PDF] [SI] [Link]

154. Lv, S.; Tang, Z.; Song, W.; Zhang, D.; Li, m.; Liu, H.; Cheng, J.; Zhong, W.; Chen, X. “Inhibiting Solid Tumor Growth In Vivo by Non-Tumor-Penetrating Nanomedicine”, Small, 2017, 13,  1600954. DOI: 10.1002/smll.201600954 [PDF] [SI] [Link]

153. Zheng, N.; Song, Z.; Liu, Y.; Yin, L.; Cheng, J. “Gene delivery into isolated Arabidopsis thaliana protoplasts and intact leaves using cationic, α-helical polypeptide”, Front. Chem. Sci. Eng.,  2017, 11, 521–528. (NSF-CHE115312; NIH-1DP2OD007246; NIH-1R21EB013379) [PDF] [Link]

152. Tian, J.; Rodgers, Z.; Min, Y.; Wan, X.; Qiu, H.; Mi, Y.; Tian, X.; Wagner, K.T.; Caster, J.M.; Qi, Y.; Roche, K.; Zhang, T.; Cheng, J.; Wang, A.Z. “Nanoparticle delivery of chemotherapy combination regimen improves the therapeutic efficacy in mouse models of lung cancer”, Nanomedicine: Nanotechnology, Biology, and Medicine, 2017, 13, 1301-1307. [PDF][SI] [Link]

151. Cai, K.; Wang, A.Z.; Yin, L.; Cheng, J. “Bio-Nano Interface: The Impact of Biological Environment on Nanomaterials and Their Delivery Properties”, J. Controlled Release, 2017, 263, 211-222. (NSF-DMR1309525; NSF-CHE1508710) [PDF] [Link]

150. Lv, S.; Wu, Y.; Dang, J.; Tang, Z.; Song, Z.; Ma, S.; Wang, X.; Chen, X.; Cheng, J.; Yin, L. “Investigation on the controlled synthesis and post-modification of poly-[(N-2-hydroxyethyl)-aspartamide]-based polymers”, Polym. Chem., 2017, 8, 1872-1877. [PDF] [SI] [Link]

2016

149. Song, Z.; Zhang, R.; Lu, H.; Gabrielson, N.P.; Yin, L.; Ponnusamy, E.; Cheng, J. “Synthesis and Biomedical Applications of Polyamino Acids”, Materials Matters, 2016, 8, 78-84. (NSF-CHE 1153122; NIH-1DP2OD007246-01; NIH-1R21EB013379-01) [PDF][Link]

148. Wang, H.; Gauthier, M.; Kelly, J. R.; Miller, R.J.; Xu, M.; O’Brien, W.D.; Cheng, J. “Targeted Ultrasound Assisted Cancer-Selective Chemical Labeling and Subsequent Cancer Imaging via Click Chemistry”, Angew. Chem. Int. Ed., 2016, 55, 5452-5456. (NIH-1DP2OD007246; NSF-DMR1309525; NIH-R37EB002641) [PDF] [SI] [Link]

147. Wang, R.; Zhang, J.; Yin, Q.; Xu, Y.; Cheng, J.; Tong, R. “Controlled Ring-Opening Polymerization of O-Carboxyanhydrides Using β-Diiminate Zinc Catalyst”, Angew. Chem. Int. Ed., 2016, 55, 13010-13014. (NSF-CHE1308485) [PDF] [SI] [Link]

146. Yin, Q.; Tang, L.; Cai, K.; Tong, R.; Sternberg, R.; Yang, X.; Dobrucki, L.W.; Borst, L.B.; Kamstock, D.; Song, Z.; Helferich, W.G.; Cheng, J.; Fan, T.M. “Pamidronate Functionalized Nanoconjugates for Targeted Therapy of Focal Skeletal Malignant Osteolysis”, PNAS, 2016, 113, 4601-4609. (NIH-1DP2OD007246; NSF-DMR1309525) [PDF] [SI] [Link]

145. Zhang, Y.; Ying, H.; Hart, K.R.; Wu, Y.; Hsu, A.J.; Coppola, A.M.; Kim, T.A.; Yang, K.; Sottos, N.R.; White, S.R.; Cheng, J. “Malleable and Recyclable Poly(urea-urethane) Thermoset Bearing Hindered Urea Bonds”, Advanced Materials, 2016, 28, 7646-7651. (NSF-CHE1508710) [PDF] [SI] [Link]

144. Baumgartner, R.; Ryba, K.; Song, Z.; Wang, R.; Harris, K.; Katz, J.S.; Cheng, J.” A delayed curing ROMP based thermosetting resin”, Polym. Chem., 2016, 7, 5093-5098. (Dow Chemical Company) [PDF][SI] [Link]

143. Bai, Y.; Nguyen, L.T.; Song, Z.; Peng, S.; Lee, J.; Zheng, N.; Kapoor, I.; Hagler, L.D.; Cai, K.; Cheng, J.; Chan, H.Y.; Zimmerman, S.C. “Integrating Display and Delivery Functionality with a Cell Penetrating Peptide Mimic as a Scaffold for Intracellular Multivalent Multi-targeting”, J. Am. Chem. Soc., 2016, 138, 9498-9507. (NSF-CHE1153122) [PDF][SI] [Link]

142. He, H.; Zheng, N.; Song, Z.; Kim, K.H.; Yao, C.; Zhang, R.; Zhang, C.; Huang, Y.; Uckun, F.M.; Cheng, J.; Zhang, Y.; Yin, L. “Suppression of Hepatic Inflammation via Systemic siRNA Delivery by Membrane-Disruptive and Endosomolytic Helical Polypeptide Hybrid Nanoparticles”, ACS NANO, 2016, 10, 1859-1870. ( NSF-CHE1508710) [PDF] [SI] [Link]

141. Kang, S.; Murphy, R.; Hwang, S.; Lee, S.; Harburg, D.; Krueger, N.; Shin, J.; Gamble, P.; Cheng, H.; Yu, S.; Liu, Z.; McCall, J.; Stephen, M.; Ying, H.; Kim, J.; Park, G.; Webb, R.; Lee, C.; Chung, S.; Wie, D.; Gujar, A.; Cheng, J.; Huang, Y.; Lee, S.; Braun, P.; Ray, W.; Rogers, J.A. ” Bioresorbable Silicon Electronic Sensors for the Brain”, Nature, 2016, 530, 71-76. [PDF][SI] [Link]

140. Wang, J.; Yuan, L.; Wang, Z.; Rahman, Md.A.; Huang, Y.; Zhu, T.; Wang, R.; Cheng, J.; Wang, C.; Chu, F.; Tang, C. “Photoinduced Metal-Free Atom Transfer Radical Polymerization of Biomass-Based Monomers”, Macromolecules, 2016, 49, 7709-7717. (NSF-DMR1252611) [PDF] [SI] [Link]

139. Xing, H.; Xu, W.; Hwang, K.; Wu, P.; Yin, Q.; Li, Z.; Cheng, J.; Lu, Y. “The Effects of Spacer Length and Composition on Aptamer-Mediated Cell-Specific Targeting with Nanoscale PEGylated Liposomal Doxorubicin”, Chem. Bio. Chem., 2016, 17, 1111-1117. [PDF][SI] [Link]

138. Song, Z.; Huang, Y.; Prasad, V.; Baumgartner, R.; Zhang, S.; Harris, K.; Katz, J.S.; Cheng, J. “Preparation of Surfactant-Resistant Polymersomes with Ultrathick Membranes through RAFT Dispersion Polymerization”, ACS Applied Materials & Interfaces, 2016, 8, 17033-17037. (Dow Chemical Company) [PDF] [SI] [Link]

137. Azzi, J.; Yin, Q.; Uehara, M.; Ohori, S.; Tang, L.; Cai, K.; Ichimura, T.; McGrath, M.; Maarouf, M.; Kefaloyianni, E.; Loughhead, S.; Petr, J.; Sun, Q.; Kwon, M.; Tullius, M.; Andrian, U.; Cheng, J.; Abdi, R. “Targeted delivery of immunomodulators to lymph nodes”, Cell Reports, 2016, 15, 1202-1213. (NIH-1DP2OD007246; NSF-CHE1308485) [PDF] [SI] [Link]

136. Wang, H.; Tang, L.; Liu, Y.; Dobrucki, I.T.; Dobrucki, L.W.; Yin, L.; Cheng, J.” In VivoTargeting of Metabolically Labeled Cancers with Ultra-Small Silica Nanoconjugates”, Theranostics, 2016, 6, 1467-1476. (NIH-1DP2OD007246-01; NSF-DMR1309525; PMC4924513)[PDF][SI] [Link]

135. Ying, H.; Cheng, J. “One-step Construction of Aminosquaraine Backbone”, Dyes and pigments, 2016, 131, 264-267. (NSF-CHE1508710) [PDF][SI][Link]

134. Li, Y.; Bai, Y.; Zheng, N.; Liu, Y.; Vincil, G.A.; Pedretti, B.J.; Cheng, J.; Zimmerman, S. “Crosslinked Dendronized Polyols as a General Approach to Brighter and More Stable Fluorophores”, Chem. Commun., 2016, 52, 3781-3784. [PDF] [SI] [Link]

133. Yen, J.; Ying, H.; Wang, H.; Yin, L.; Uckun, F.; Cheng, J. “CD44 Mediated Non-Viral Gene Delivery into Human Embryonic Stem Cells via Hyaluronic Acid Coated Nanoparticles”, ACS Biomater. Sci. Eng., 2016, 2, 326-335. (NIH-1DP2OD007246; NIH-1R21EB013379; NSF-CHE1153122) [PDF] [Link]

2015

132. Cheng, J.; Pun, S.H. “Polymeric biomaterials for cancer nanotechnology”, Biomater. Sci., 2015, 3, 891-893. [PDF][Link]

131. Xiong, M.; Lee, M.W.; Mansbach, R.A.; Song, Z.; Bao, Y.; Jr. Peek, R. M.; Yao, C.; Chen, L.; Ferguson, A.L.; Wong, GC.L.; Cheng, J. “Helical Antimicrobial Polypeptides with Radial Amphiphilicity”, PNAS, 2015, 112, 13155-13160. [PDF] [SI] [Link]

130. Torabi, S.F.; Wu, P.; McGhee, C.E.; Chen, L.; Hwang, K.; Zheng, N.; Cheng, J.; Lu, Y. “In vitro selection of a sodium-specific DNAzyme and its application in intracellular sensing”, PNAS, 2015, 112, 5903-5908. (PMC4434688; NIH-ES016865) [PDF][SI] [Link]

129. Cai, K.; He, X.; Song, Z.; Yin, Q.; Zhang, Y.; Uckun, F.M.; Jiang, C.; Cheng, J. “Dimeric Drug Polymeric Nanoparticles with Exceptionally High Drug Loading and Quantitative Loading Efficiency”, J. Am. Chem. Soc., 2015, 137, 3458-3461. (NIH-1DP2OD007246-01; NIH-1R21CA152627;  NSF-DMR0748834; NSF-DMR1309525) [PDF] [SI] [Link]

128. Priftis, D.; Leon, L.; Song, Z.; Perry, S.L.; Margossian, K.O.; Tropnikova, A.; Cheng, J.; Tirrell, M. “Self-Assembly of Alpha-Helical Polypeptides Driven by Complex Coacervation”, Angew. Chem. Int. Ed., 2015, 54, 11128-11132. (NSF-CHE1153122) [PDF] [SI] [Link]

127. Tang, L.; Yin, Q.; Xu, Y.; Zhou, Q.; Cai, K.; Yen, J.; Dobrucki, L.W.; Cheng, J. “Bioorthogonal Oxime Ligation Mediated in Vivo Cancer Targeting”, Chemical Science, 2015, 6, 2182-2186. (NIH-1DP2OD007246-01; NSF-DMR13-09525; PMC4486360) [PDF][SI][Link]

126. Tang, L.; Tong, R.; Coyle, V.J.; Yin, Q.; Pondenis, H.; Borst, L.B.; Cheng, J.; Fan, T.M. “Targeting Tumor Vasculature with Aptamer Functionalized Doxorubicin-Polylactide Nanoconjugates for Enhanced Cancer Therapy”, ACS Nano, 2015, 9, 5072-5081. (NIH-1DP2OD007246-01; NIH-1R21CA152627) [PDF] [SI] [Link]

125. Yin, Q.; Yin, L.; Wang, H.; Cheng, J. “Synthesis and biomedical applications of functional poly(alpha-hydroxy acids) via ring-opening polymerization of O-carboxyanhydrides”, Acc. Chem. Res., 2015, 48, 1777-1787. (NSF-CHE1308485; NIH-1DP2OD007246-01) [PDF] [Link]

124. Wu, X.; He, C.; Wu, Y.; Chen, X.; Cheng, J. “Nanogel-Incorporated Physical and Chemical Hybrid Gels for Highly Effective Chemo-Protein Combination Therapy”, Adv. Funct. Mater., 2015, 25, 6744–6755. [PDF] [SI] [Link]

123. Uckun, F.M.; Mitchell, L.G.; Qazi, S.; Myers, D.E.; Ma, H.; Zheng, N.; Song, Z.; Liu, Y.; Cheng, J. “Development of Polypeptide-Based Nanoparticles for Non-Viral Delivery of CD22 RNA Trans-splicing Molecule as a New Precision Medicine Candidate Against B-lineage ALL”, EBioMedicine, 2015, 2, 649-659. (NIH-1DP2OD007246-01; NSF-CHE1308485; PMC4534679) [PDF] [Link]

122. Uckun, F.M.; Qazi, S.; Cheng, J.; Myers, D.E. “Liposomal Nanoparticles of a Spleen Tyrosine Kinase P-site Inhibitor Amplify the Potency of Low Dose Total Body Irradiation Against Aggressive B-precursor Leukemia and Yield Superior Survival Outcomes in Mice EBioMedicine”, EBioMedicine, 2015, 2, 554-562. (NIH-1DP2OD007246-01; PMC4535154) [PDF][SI] [Link]

121. Uckun, F.M.; Ma, H.; Cheng, J.; Myers, D.E.; Qazi, S. “CD22deltaE12 as a molecular target for RNAi therapy”, British Journal of Haematology, 2015, 169, 401-414. (NIH-1DP2OD007246-01) [PDF] [SI] [Link]

120. Wang, H.; Xu, M.; Xiong, M.; Cheng, J. “Reduction-Responsive Dithiomaleimide-Based Nanomedicine with High Drug Loading and FRET-Indicated Drug Release “, Chem. Commun., 2015, 51, 4807-4810. (NSF-DMR1309525; NIH-1DP2OD007246-01) [PDF] [SI] [Link]

119. Zhang, Y.; Yin, Q.; Yen, J.; Li, J.; Ying, H.; Wang, H.; Hua, Y.; Chaney, E.; Boppart, S.; Cheng, J. “Non-Invasive, Real-Time Reporting Drug Release In Vitro and In Vivo“, Chem.Commun., 2015, 51, 6948-6951. (NIH-1DP2OD007246-01; NIH-R25CA154015A) [PDF] [SI] [Link]

118. Song, Z.; Kim, H.; Ba, X.; Baumgartner, R.; Lee, J.; Tang, H.; Leal, C.; Cheng, J. “Polypeptide Vesicles with Densely Packed Multilayer Membranes”, Soft Matter, 2015, 11, 4091-4098. (Dow Chemical Company; NSF-CHE1308485) [PDF] [SI] [Link]

117. Baumgartner, R.; Song, Z.; Zhang, Y.; Cheng, J. “Functional Polyesters Derived from Alternating Copolymerization of Norbornene Anhydride and Epoxides”, Polym. Chem., 2015, 6, 3586-3590. (Dow Chemical Compay) [PDF] [SI] [Link]

116. Andrade, B.; Song, Z.; Li, J.; Zimmerman, S.; Cheng, J.; Moore, J.S.; Harris, K.; Katz, J. “New Frontiers for Encapsulation in the Chemical Industry”, ACS Appl. Mater. Interfaces, 2015, 7, 6359−6368. (Dow Chemical Company) [PDF] [Link]

115. Wang, H.C.; Zhang, Y.; Possanza, C.; Zimmerman, S.; Cheng, J.; Moore, J.; Harris, K.; Katz, J. “Trigger Chemistries for Better Industrial Formulations”, ACS Appl. Mater. Interfaces, 2015, 7, 6369-6382. (Dow Chemical Company) [PDF] [Link]

114. Uckun, F.M.; Qazi, S.; Cheng, J. “Targeting leukemic stem cells with multifunctional bioactive polypeptide nanoparticles”, Future Oncology, 2015, 11, 1149-1152. (NIH-1DP2OD007246-01) [PDF] [Link]

113. Lee, J.S.; Deng, X.; Han, P.; Cheng, J. “Dual Stimuli-Responsive Poly(beta-amino ester) Nanoparticles for On-Demand Burst Release”, Macromol. Biosci., 2015, 15, 1314-1322. (NIH-1DP2OD007246-01) [PDF] [SI] [Link]

112. Zheng, N.; Song, Z.; Liu, Y.; Zhang, R.; Zhang, R.; Yao, C.; Uckun, F.M.; Yin, L.; Cheng, J. “Redox-responsive, reversibly-crosslinked thiolated cationic helical polypeptides for efficient siRNA encapsulation and delivery”, J. Controlled Release, 2015, 205, 231-239. (NSF-CHE1153122; NIH-1DP2OD007246-01; NIH-1R21EB013379-01) [PDF] [Link]

111. Cai, K.; Yen, J.; Yin, Q.; Liu, Y.; Song, Z.; Lezmi, S.; Zhang, Y.; Yang, X.; Helferich, W.G.; Cheng, J. “Redox-Responsive Self-Assembled Chain-Shattering Polymeric Therapeutics”, Biomater. Sci., 2015, 3, 1061-1065. (NSF-DMR 0748834; NSF-DMR1309525; NIH-1DP2OD007246-01; NIH-1R21CA152627) [PDF] [SI] [Link]

110. Ma, L.; Baumgartner, R.; Zhang, Y.; Song, Z.; Cai, K.; Cheng, J. “UV-Responsive Degradable Polymers Derived from 1-(4-Aminophenyl) ethane-1, 2-diol”, J. of Polym. Sci., Part A: Polym. Chem., 2015, 53, 1161-1168. (Dow Chemical Company) [PDF] [SI] [Link]

109. Gauthier, M.; Yin, Q.; Cheng, J.; O’Brien W.D. “Design of Albumin-Coated Microbubbles Loaded With Polylactide Nanoparticles”, J. Ultrasound Med., 2015, 34, 1363-1372. (NIH-R37EB002641; NIH-1DP2OD007246) [PDF] [Link]

108. Yin, L.; Chen, Y.; Zhang, Z.; Yin, Q.; Zheng, N.; Cheng, J. “Biodegradable Micelles Capable of Mannose-Mediated Targeted Drug Delivery to Cancer Cells”, Macromol. Rapid Commun., 2015, 36, 483-489. (NSF-CHE1153122; NIH-1DP2OD007246; NIH-1R21EB013379) [PDF] [SI] [Link]

107. Zhang, R.; Song, Z.; Yin, L.; Lu, H.; Gabrielson, N.P.; Cheng, J. “Ionic α-Helical Polypeptides towards Non-Viral Gene Delivery”, WIREs Nanomedicine & Nanobiotechnology, 2015, 7, 98-110. (NSF-CHE1153122; NIH-1DP2OD007246-01; NIH-1R21EB013379-01) [PDF] [Link]

2014

106. Mahsan, K.; Chaudhury, I.; Cheng, J.; Safari, M.; Sadeghi, R.; Habibi-Rezaei, M.; Kokini, J. “Immobilization of endo-inulinase on non-porous aminofunctionalized silica nanoparticles”, Journal of Molecular Catalysis B: Enzymatic, 2014, 104, 48-55. [PDF] [Link]

105. Qu, Q.; Dong, L.; Louis, K.R.; Li, X.; Yang, H.; Sun, Q.; Crandall, S.R.; Tsang, S.; Zhou, J.; Cox, C.L.; Cheng, J.; Wang, F. “High-efficiency motor neuron differentiation from human pluripotent stem cells and the function of Islet-1”, Nature Communications, 2014, 5, 3449. [PDF][SI] [Link]

104. Ying, H.; Zhang, Y.; Cheng, J. “Dynamic urea bond for the design of reversible and self-healing polymers”, Nature Communications, 2014, 5, 3218. (NSF-CHE1153122; NIH-1DP2OD007246-01) [PDF][SI][Link]

103. Tang, L.; Yang, X.; Yin, Q.; Cai, K.; Wang, H.; Chaudhury, I.; Yao, C.; Zhou, Q.; Kwon, M.; Hartman, J.A.; Dobrucki, I.T.; Dobrucki, L.W.; Borst, L.B.; Lezmi, S.; Helferich, W.G.; Ferguson, A.L.; Fan, T.M.; Cheng, J. “Investigating the optimal size of anticancer nanomedicine”, PNAS, 2014, 111, 15344-15349. (NIH-1DP2OD007246-01; NIH-1R21CA152627; PMC4217425) [PDF][SI] [Link]

102. Ying, H.; Cheng, J. “Hydrolysable Polyureas Bearing Hindered Urea Bonds”, J. Am. Chem. Soc., 2014, 136, 16974-16977. (NSF-CHE1153122; NIH-1DP2OD007246-01) [PDF][SI][Link]

101. Uckun, F.M.; Qazi, S.; Ma, H.; Yin, L.; Cheng, J. “A rationally designed nanoparticle for RNA interference therapy in B-lineage lymphoid malignancies”, EBioMedicine, 2014, 1, 141-155. (NIH-1DP2OD007246-01; PMC4292938) [PDF][SI] [Link]

100. Yin, L.; Huang, X.; Xu, H.; Zhang, Y.; Lam, J.; Cheng, J.; Rogers, J.A. ” Materials, Designs, and Operational Characteristics for Fully Biodegradable Primary Batteries”, Advanced Materials, 2014, 26, 3879-3884. [PDF][SI] [Link]

99. Yen, J.; Yin, L.; Cheng, J. “Enhanced Non-Viral Gene Delivery to Human Embryonic Stem Cells via Small Molecule-Mediated Transient Alteration of Cell Structure”, J. Mater. Chem. B., 2014, 2, 8098-8105. (NIH-1DP2OD007246-01; NIH-1R21EB013379-01; NSF-CHE1153122) [PDF][SI] [Link]

98. Zhang, Y.; Wang, R.; Hua, Y.; Baumgartner, R.; Cheng, J. “Trigger-Responsive Poly(β-amino ester) Hydrogels”, ACS Macro Letters, 2014, 3, 693-697. (Dow Chemical Company) [PDF][SI] [Link]

97. Tong, R.; Tang, L.; Ma, L.; Tu, C.; Baumgartner, R.; Cheng, J. “Smart Chemistry in Polymeric Nanomedicines”, Chem. Soc. Rev., 2014, 43, 6982-7012. [PDF] [Link]

96. Myers, D.E.; Yiv, S.; Qazi, S.; Ma, H.; Cely, I.; Shahidzadeh, A.; Arellano, M.; Finestone, E.; Gaynon, P.; Termuhlen, A.; Cheng, J.; Uckun, F. “CD19-antigen Q1 specific nanoscale liposomal formulation of a SYK Q2 P-site inhibitor causes apoptotic destruction of human B-precursor leukemia cells”, Integr. Biol., 2014, 6, 766-780. (NIH-1DP2OD007246-01) [PDF] [Link]

95. Zheng, C.; Niu, L.; Pan, W.; Zhou, J.; Lv, H.; Cheng, J.; Liang, D. “Long-term kinetics of DNA interacting with polycations”, Polymer, 2014, 13, 2464- 2471. [PDF] [Link]

94. Karimi, M.; Chaudhury, I.; Cheng, J.; Safari, M.; Sadeghi, R.; Habibi-Rezaei, M.; Kokini, J.;” Immobilization of endo-inulinase on non-porous aminofunctionalized silica nanoparticles”, Journal of Molecular Catalysis B: Enzymatic, 2014, 104, 48-55.

93. Deng, X.; Zheng, N.; Song, Z.; Yin, L.; Cheng, J. “Trigger-responsive, fast-degradable poly(β-amin ester)s for enhanced DNA unpackaging and reduced toxicity”, Biomaterials, 2014, 35, 5006-5015. (NSF-CHE1153122; NIH-1DP2OD007246; NIH-1R21EB013379) [PDF][SI] [Link]

92. Song, Z.; Zheng, N.; Ba, X.; Yin, L.; Zhang, R.; Ma, L.; Cheng, J. “Polypeptides with Quaternary Phosphonium Side Chains: Synthesis, Characterization, and Cell-Penetrating Properties”, Biomacromolecules, 2014, 15, 1491-1497. (NSF-CHE1153122; NIH-1DP2OD007246-01; PMC399387) [PDF][SI] [Link]

91. Zhang, R.; Zheng, N.; Song, Z.; Yin, L.; Cheng, J.; “The effect of side-chain functionality and hydrophobicity on the gene delivery capabilities of cationic helical polypeptides”, Biomaterials, 2014, 35, 3443-3454. (NSF-CHE1153122; NIH-1DP2OD007246-01; NIH-1R21EB013379-01) [PDF][SI] [Link]

90. Uppada, S.B.; Erickson, T.; Wojdyla, L.; Moravec, D.N.; Song, Z.; Cheng, J.; Puri, N. “Novel delivery system for T-oligo using a nanocomplex formed with an alpha helical peptide for melanoma therapy”, International Journal of Nanomedicine, 2014, 9. [PDF] [Link]

89. Lu, H.; Wang, J.; Song, Z.; Yin, L.; Zhang, Y.; Tang, H.; Tu, C.; Lin, Y.; Cheng, J. “Recent Advances in Amino Acid N-Carboxyanhydrides and Synthetic Polypeptides: Chemistry, Self-Assembly and Biological Applications”, Chem. Commun., 2014, 50, 139-155. [PDF] [Link]

88. Yin, Q.; Tong, R.; Yin, L.; Fan, T.M.; Cheng, J. “Anticancer Camptothecin-N-Poly(lactic acid) Nanoconjugates with Facile Hydrolysable Linker”, Polym. Chem., 2014, 5, 1581-1585. (NSF-DMR07-48834; NSF-DMR1309525; NIH-1DP2OD007246-01; NIH-1R21CA152627) [PDF][SI][Link]

87. Zheng, N.; Yin, L.; Song, Z.; Ma, L.; Tang, H.; Gabrielson, N.P.; Lu, H.; Cheng, J. “Maximizing gene delivery efficiencies of cationic helical polypeptides via balanced membrane penetration and cellular targeting”, Biomaterials, 2014, 35, 1302-1314. (NIH-1DP2OD007246-01; NIH-1R21EB013379-01; NSF-CHE0809420) [PDF][SI][Link]

2013

86. Zhang, Y.; Yin, Q.; Yin, L.; Ma, L.; Tang, L.; Cheng, J. “Chain-Shattering Polymeric Therapeutics with On-Demand Drug-Release Capability”, Angew. Chem. Int. Ed., 2013, 52, 6435-6439. (Dow Chemical Company; PMC3800742; NIHMS502266) [PDF] [SI] [Link]

85. Yin, L.; Song, Z.; Qu, Q.; Kim, K.H.; Zheng, N.; Yao, C.; Chaudhury, I.; Tang, H.; Gabrielson, N.P.; Uckun, F.M.; Cheng, J. “Supramolecular self-assembled nanoparticles mediate oral delivery of therapeutic TNF-α siRNA against systemic inflammation”, Angew. Chem. Int. Ed., 2013, 52, 5757-5761. (NSF-CHE1153122; NIH-1DP2OD007246-01; NIH-1R21EB013379-01) [PDF] [SI] [Link]

84. Yin, L.; Tang, H.; Kim, K.; Zheng, N.; Song, Z.; Gabrielson, N.P.; Lu, H.; Cheng, J. “Light‐Responsive Helical Polypeptides Capable of Reducing Toxicity and Unpacking DNA: Toward Nonviral Gene Delivery”, Angew. Chem. Int. Ed. Engl., 2013, 52, 9182–9186. ( NSF-CHE1153122; NIH-1DP2OD007246; NIH-1R21EB013379) [PDF][SI][Link]

83. Yin, Q.; Yap, F.Y.; Yin, L.; Ma, L.; Zhou, Q.; Dobrucki, L.W.; Fan, T.M.; Gaba, R.C.; Cheng, J. “Poly(iohexol) Nanoparticles As Contrast Agents for In Vivo X-ray Computed Tomography Imaging”, J. Am. Chem. Soc., 2013, 135, 13620-13623. (NIH-1DP2OD007246-01; NIH-1R21CA152627; PMC4232444; NIH-MS522439) [PDF][SI] [Link]

82. Wang, J.; Xia, H.; Zhang, Y.; Lu, H.; Kamat, R.; Dobrynin, A.V.; Cheng, J.; Lin, Y. “Nucleation-Controlled Polymerization of Nanoparticles into Supramolecular Structures”, J. Am. Chem. Soc., 2013, 135, 11417-11420. (NIH-1R21EB013379-01; NSF-CHE1153122) [PDF] [SI] [Link]

81. Tang, H.; Yin, L.; Kim, K.H.; Cheng, J. “Helical Poly(arginine) Mimics with Superior Cell-Penetrating and Molecular Transporting Properties”, Chem. Sci., 2013, 4, 3839-3844. (NSF-CHE1153122; NIH-1DP2OD007246-01; NIH-1R21EB013379-01; PMC4232443; NIH-MS516191) [PDF] [SI] [Link]

80. Yin, L.; Song, Z.; Kim, K.H.; Zheng, N.; Gabrielson, N.P.; Cheng, J. “Non-Viral Gene Delivery via Membrane-Penetrating, Mannose-Targeting Supramolecular Self-Assembled Nanocomplexes”, Adv. Mater., 2013, 25, 3063-3070. (NSF-CHE1153122; NIH-1DP2OD007246-01; NIH-1R21EB013379-01; PMC3757134; NIH-MS499301) [PDF][SI] [Link]

79. Uckun, F.M.; Qazi, S.; Cely, I.; Sahin, K.; Shahidzadeh, A.; Ozercan, I.; Yin, Q.; Gaynon, P.; Termuhlen, A.; Cheng, J.; Yiv, S. “Nanoscale liposomal formulation of a SYK P-site inhibitor against B-precursor leukemia”, Blood, 2013, 121, 4348-4354. (NIH-1DP2OD007246-01; PMC3663427) [PDF] [Link]

78. Yin, L.; Song, Z.; Kim, K.; Zheng, N.; Tang, H.; Lu, H.; Gabrielson, N.; Cheng, J. “Reconfiguring the architectures of cationic helical polypeptides to control non-viral gene delivery”, Biomaterials, 2013, 34, 2340-2349.

77. Song, Z.; Zhang, R.; Lu, H.; Gabrielson, NP; Yin, L.; Ponnusamy, E.; Cheng, J. “Synthesis and Biomedical Applications of Polyamino Acids”, Materials Matters, 2013, 8, 78-84.

76. Wang, H.; Tang, L.; Tu, C.; Song, Z.; Yin, Q.; Yin, L.; Zhang, Z.; Cheng, J. “Redox-Responsive, Core-Cross-Linked Micelles Capable of On-Demand, Concurrent Drug Release and Structure Disassembly”, Biomacromolecules, 2013, 14, 3706-3712. (NIH-1DP2OD007246-01; NSF-DMR1309525; PMC4232441; NIH-MS523142) [PDF][SI] [Link]

75. Zhang, Y.; Yin, Q.; Lu, H.; Xia, H.; Lin, Y.; Cheng, J. “PEG-Polypeptide Dual Brush Block Copolymers: Synthesis and Application in Nanoparticle Surface PEGylation”, ACS Macro Letters, 2013, 2, 809-813. (NSF-CHE1153122; NIH-1DP2OD007246-01; PMC3804265; NIH-MS518036) [PDF][SI] [Link]

74. Xing, H.; Tang, L.; Yang, X.; Hwang, K.; Wang, W.; Yin, Q.; Wong, N.Y.; Dobrucki, L.W.; Yasui, N.; Katzenellenbogen, J.A.; Helferich, W.G.; Cheng, J.; Lu, Y. “Selective delivery of an anticancer drug with aptamer-functionalized liposomes to breast cancer cells in vitro and in vivo“, J. of Mater. Chem. B, 2013, 1, 5288-5297. (NIH-1DP2OD007246-01; NIH-1R21CA152627; PMC-3800741; NIH-MS514388) [PDF] [SI] [Link]

73. Tang, L.; Cheng, J. “Nonporous Silica Nanoparticles for Nanomedicine Application”, Nano Today, 2013, 8, 290-312. (NIH-1DP2OD007246-01; NIH-1R21CA152627; PMC3757135; NIH-MS481146) [PDF] [Link]

72. Yen, J.; Zhang, Y.; Gabrielson, N.P.; Yin, L.; Guan, L.; Chaudhury, I.; Lu, L.; Wang, F.; Cheng, J. “Cationic, helical polypeptide-based gene delivery for IMR-90 fibroblasts and human embryonic stem cell”, Biomater. Sci., 2013, 1, 719-727. (NIH-1DP2OD007246-01; NIH-1R21EB013379-01; NSF-CHE1153122; PMC3757133; NIH-MS464545) [PDF] [Link]

71. Yin, Q.; Tong, R.; Xu, Y.; Baek, K.; Dobrucki, L.W.; Fan, T.M.; Cheng, J. “Drug-Initiated Ring-Opening Polymerization of O-Carboxyanhydrides for the Preparation of Anticancer Drug-Poly(O-Carboxyanhydride) Nanoconjugates”, Biomacromolecules, 2013, 14, 920-929. (NSF-DMR07-48834; NIH-1DP2OD007246-01; NIH-1R21CA152627; PMC3671392; NIH-MS450799) [PDF] [SI] [Link]

70. Cameron, J.A.; Milner, D.J.; Lee, J.S.; Cheng, J; Fang, N.X.; Jasiuk, I.M. “Employing the biology of successful fracture repair to heal critical size bone defects”, Current Topics in Microbiology and Immunology, 2013, 367, 113-132. [PDF] [Link]

69. Yin, L.; Song, Z.; Kim, H.K.; Zheng, N.; Tang, H.; Lu, H.; Gabrielson, N.P.; Cheng, J. “Reconfiguring the architectures of cationic helical polypeptides to control non-viral gene delivery”, Biomaterials, 2013, 34, 2340-2349. (NSF-CHE1153122; NIH-1DP2OD007246-01; NIH-1R21EB013379-01) [PDF] [SI] [Link]

69. Zhang, R.; Lu, H.; Gabrielson, N.P.; Yin, L.; Cheng, J. “Cationic α-Helical Polypeptide Template for Nonviral Gene Delivery”, SurFACTS in Biomaterials, 2013, 18, 2. (NSF-CHE0809420; NIH-1DP2OD007246-01; NIH-1R21EB013379-01) [PDF]

68. Mirshafiee, V.; Mahmoudi, M.; Lou, K.; Cheng, J.; Kraft, M.L. “Protein Corona Significantly Reduces Active Targeting Yield”, Chem.Commun., 2013, 49, 2557-2559. (NIH-1R21CA152627; PMC3671387; NIH-MS447802) [PDF] [SI] [Link]

67. Tang, L.; Gabrielson, N.P.; Uckun, F.M.; Fan, T.M.; Cheng, J. “Size-dependent tumor penetration and in vivo efficacy of monodisperse drug-silica nanoconjugates”, Mol. Pharmaceutics, 2013, 10, 883-892. (NIH-1DP2OD007246-01; NIH-1R21CA152627; PMC3697826; NIH-MS445569) [PDF] [SI] [Link]

66. Zhang, Z.; Yin, L.; Tu, C.; Song, Z.; Zhang, Y.; Xu, Y.; Tong, R.; Zhou, Q.; Ren, J.; Cheng, J. “Redox-Responsive, Core Cross-Linked Polyester Micelles”, ACS Macro Lett., 2013, 2, 40-44. (NIH-1DP2OD007246-01; NIH-1R21EB013379-01; NSF-CHE1153122; NSF-DMR07-48834; PMC3606897; NIH-MS431405) [PDF] [SI] [Link]

65. Zhang, Y.; Ma, L.; Deng, X.; Cheng, J. “Trigger-Responsive Chain-Shattering Polymers”, Polym. Chem., 2013, 4, 224-228. (Dow Chemical Company) [PDF] [SI] [Link]

2012

64. Tang, L.; Yang, X.; Dobrucki, L.W.; Chaudhury, I.; Yin, Q.; Yao, C.; Lezmi, S.; Helferich, W.G.; Fan, T.M.; Cheng, J. “Aptamer-functionalized, ultra-small, monodisperse silica nanoconjugate for targeted dual-modal imaging of lymph nodes with metastatic tumors“, Angew. Chem. Int. Ed., 2012, 51, 12721-12726. (NIH-1DP2OD007246-01; NIH-1R21CA152627; NIH-MS512609) [PDF] [SI] [Link]

63. Gabrielson, N.P.; Lu, H.; Yin, L.; Li, D.; Wang, F.; Cheng, J. “Reactive and Bioactive Cationic a-Helical Polypeptide Template for Non-Viral Gene Delivery”, Angew. Chem. Int. Ed., 2012, 51, 1143-1147. (NSF-CHE0809420; NIH-1R21EB009486-01; NIH-1DP2OD007246-01; NIH-1R21CA152627; PMC3555134; NIH-MS400098) [PDF] [SI] [Link]

62. Tong, R.; Cheng, J. “Zinc complex mediated regioselective O-acylation of therapeutic agents”, Chemical Science, 2012, 3, 2234-2239. [PDF] [SI] [Link]

61. Gabrielson, N. P.; Lu, H.; Yin, L.; Kim, K.H.; Cheng, J. “A Cell-Penetrating Helical Polymer for siRNA Delivery to Mammalian Cells”, Molecular Therapy, 2012, 20, 1599-1609. (NSF-CHE0809420; NIH-1R21EB013379-01; NIH-1DP2OD007246-01; PMC3412491) [PDF] [Link]

60. Tong, R.; Gabrielson, N.P.; Fan, T.M.; Cheng, J. “Polymeric Nanomedicine Based on Poly(lactide) and Poly(lactic-co-glycolide)”, Current Opinion in Solid State & Materials Science, 2012, 16, 323-332. (PMC3728009; NIH-MS439167) [PDF] [Link]

59. Zhang, Z.; Yin, L.; Xu, Y.; Ren, J.; Cheng, J. “Facile Functionalization of Polyesters through Thiol-yne Chemistry for the Design of Degradable, Cell‒Penetrating and Gene Delivery Dual‒Functional Agents”, Biomacromolecules, 2012, 13, 3456-3462. (NIH-1R21EB013379-01; NIH-1DP2OD007246-01; NSF-CHE1153122; PMC3606898; NIH-MS417829) [PDF] [SI] [Link]

58. Tang, H.; Yin, L.; Lu, H.; Cheng, J. “Water-Soluble Poly(L-serine)s with Elongated and Charged Side-Chains: Synthesis, Conformations and Cell-Penetrating Properties”, Biomacromolecules, 2012, 13, 2609-2615. (NIH-1R21EB013379-01; NIH-1DP2OD007246-01; PMC3555145; NIH-MS401030) [PDF] [SI] [Link]

57. Cely, I.; Yiv, S.;Yin, Q.; Shahidzadeh, A.; Tang, L.; Cheng, J.; Uckun, F.M. “Targeting Mantle Cell Lymphoma with Anti-SYK Nanoparticles”, J. Anal. Oncol., 2012, 1, 1-9. (NIH-1DP2OD007246-01; PMC3668349; NIH-MS406536) [PDF] [Link]

56. Li, L.; Yin, Q.; Cheng, J.; Lu, Y. “Polyvalent Mesoporous Silica Nanoparticle-Aptamer Bioconjugates Target Breast Cancer Cells”, Adv. Healthcare Mater., 2012, 1, 567-572. (NIH-1DP2OD007246-01; NIH-1R21CA152627) [PDF] [SI] [Link]

55. Tang, L.; Azzi, J.; Kwon, M.; Mounayar, M.; Tong, R.; Yin, Q.; Moore, R.; Skartsis, N.; Fan, T.M.; Abdi, R.; Cheng, J. “Immunosuppressive Activity of Size-Controlled PEG-PLGA Nanoparticles Containing Encapsulated Cyclosporine A”, Journal of Transplantation, 2012, 896141, 1-9. (NIH-1DP2OD007246-01; NIH-1R21CA152627; PMC3321582) [PDF] [Link]

54. Tang, L.; Fan, T.M.; Borst, L.B.; Cheng, J. “Synthesis and Biological Response of Size-Specific, Monodisperse Drug-Silica Nanoconjugates”, ACS Nano., 2012, 6, 3954-3966. (NIH-1DP2OD007246-01; NIH-1R21CA152627; PMC3555148; NIH-MS372943) [PDF] [SI][Link]

53. Lu, Y.; Yin, L.; Zhang, Y.; Zhang, Z.; Xu, Y.; Tong, R.; Cheng, J. “Synthesis of Water-Soluble Poly(α-hydroxy acids) from Living Ring-Opening Polymerization of O-Benzyl-L-serine Carboxyanhydrides”, ACS Macro Letters, 2012, 1, 441-444. (DMR 07-48834, 1DP2OD007246-01, 1R21EB013379-01; PMC3555137, NIHMS363858) [PDF] [SI] [Link]

52. Tong, R.; Cheng, J. “Drug-Initiated, Controlled Ring-Opening Polymerization for the Synthesis of Polymer-Drug Conjugates”, Macromolecules, 2012, 45, 2225-2232. (NSF-DMR07-48834; NIH-1DP2OD007246-01; PMC3555138; NIH-MS359696) [PDF][SI] [Link]

51. Chen, K.; Tang, L.; Garcia, M.A.; Wang, H.; Lu, H.; Lin, W.; Hou, S.; Yin, Q.; Shen, C.K.F.; Cheng, J.; Tseng, H.R. “The therapeutic efficacy of camptothecin-encapsulated supramolecular nanoparticles”, Biomaterials, 2012, 33, 1162-1169. (NIH-1R21CA152627; PMC3786683; NIH-MS333953) [PDF] [SI] [Link]

2011

50. Lu, H.; Wang, J.; Bai, Y.; Lang, J.W.; Liu, S.; Lin, Y.; Cheng, J. “Ionic Polypeptides with Unusual Helical Stability”, Nature Communications, 2011, 2, 206. (NSF-CHE0809420; NSF-DMR 07-48834; NIH-1R21EB009486-01; NIH-1DP2OD007246-01; NIH-1R21CA139329) [PDF] [Link]

49. Mishra, A.; Lai, G.H.; Schmidt, N.W.; Sun, V.Z.; Rodriguez, A.R., Tong, R.; Tang, L.; Cheng, J.; Deming, T.J.; Kamei, D.T.; Wong, G.C.L. “Translocation of HIV TAT peptide and analogues induced by multiplexed membrane and cytoskeletal interactions”, PNAS, 2011, 108, 16883-16888. (PMC3193208) [PDF] [SI] [Link]

48. Wang, J.; Lu, H.; Kamat, R.; Pingali, S.V.; Urban, V.S.; Cheng, J.; Lin, Y. “Supramolecular Polymerization from Polypeptide-Grafted Comb Polymers”, J. Am. Chem. Soc., 2011, 133, 12906-12909. (NSF-CHE0809420) [PDF][SI] [Link]

47. Tong, R.; Tang, L.; Yin, Q.; Cheng, J. “Drug-polyester conjugated nanoparticles for cancer drug delivery”, IEEE. Eng. Med. Biol. Soc., 2011, 3, 8337-8339. (NSF-DMR07-48834) [PDF] [Link]

46. Wang, J.; Lu, H.; Ren, Y.; Zhang, Y.; Morton, M.; Cheng, J.; Lin, Y. “Interrupted Helical Structure of Grafted Polypeptides in Brush-Like Macromolecules”, Macromolecules, 2011, 44, 8699-8708. (NSF-CHE0809420; NIH-1R21EB013379-01) [PDF][SI] [Link]

45. Bai, Y.; Lu, H.; Ponnusamy, E.; Cheng, J. “Synthesis of Hybrid Block Copolymers via Integrated Ring-Opening Metathesis Polymerization and Polymerization of NCA”, Chem. Commun., 2011, 47, 10830-10832. (NSF-CHE0809420; NIH-1R21EB009486-01; NIH-1DP2OD007246-01) [PDF][SI] [Link]

44. Zhang, Y.; Lu, H.; Yao, L.; Cheng, J. “Water-Soluble Polypeptides with Elongated, Charged Side Chains Adopt Ultrastable Helical Conformations”, Macromolecules, 2011, 44, 6641-6644. (NSF-CHE0809420; NIH-1R21EB009486-01; NIH-1DP2OD007246-01; PMC3204311; NIH-MS317340) [PDF][SI] [Link]

43. Lu, H.; Bai, Y.; Wang, J.; Gabrielson, N.; Wang, F.; Lin, Y.; Cheng, J. “Ring-Opening Polymerization of g-(4-Vinylbenzyl)-L-Glutamate N-Carboxyanhydride for the Synthesis of Functional Polypeptides”, Macromolecules, 2011, 44, 6237-6240. (NSF-CHE0809420; NIH-1R21EB009486-01; NIH-1DP2OD007246-01; NIH-1R21CA139329Z; PMC3222942; NIH-MS312521) [PDF][SI] [Link] [Cover]

42. Cheng, J.; Deming, T.J. “Synthesis of Polypeptides by Ring-Opening Polymerization of α-Amino Acid N-Carboxyanhydrides”, Top Curr. Chem., 2011, 310, 1-26. [PDF] [Link]

41. Li, D.; Zhou, J.; Chowdhury, F.; Cheng, J.; Wang, N.; Wang, F. “Role of mechanical factors in fate decisions of stem cells.” Regen. Med., 2011, 6, 229-240. (PMC3128460; NIH-MS303388) [PDF] [Link]

2010

40. Chan, J.M.; Zhang, L. F.; Tong, R.; Ghosh, D.; Gao, W.; Liao, G.; Yuet, K.; Gray, D.; Rhee, J.W.; Cheng, J.; Golomb, G.; Libby, P; Langer, R.; Farokhzad, O. “Spatiotemporal Controlled Delivery of Nanoparticles to Injured Vasculature”, PNAS, 2010, 107, 2213-2218. (PMC2836709) [PDF] [Link]

39. Li, C.; Zhang, Y.; Hu, J..; Cheng, J.; Liu, S. “Reversible Three-State Switching of Multicolor Fluorescence Emission via Multiple Stimuli-Modulated FRET Processes within Thermoresponsive Polymeric Micelles”, Chem. Int. Ed., 2010, 49, 5120-5124. [PDF] [SI] [Link]

38. Gabrielson, N.; Xu, Y.; Cheng, J. “Multiplexed supramolecular self-assembly for non-viral gene delivery”, Biomaterials, 2010, 31, 9117-9127. (NSF-DMR07-48834; NIH-1R21CA139329; NIH-1R21EB009486; PMC2952339; NIH-MS229754) [PDF] [Link]

37. Azzi, J.; Tang, L.; Moore, R.; Tong, R.; Haddad, N.El.; Akiyoshi, T.; Mfarrej, B.; Yang, S.; Jurewicz, M.; Ichimura, T.; Lindeman, N.; Cheng, J.; Abdi, R. “Polylactide-Cyclosporin A Nanoparticles for Targeted Immunosuppression”, FASEB J., 2010, 24, 3927-3938. (NSF-DMR07-48834; NIH-1R21CA139329-01; NIH-1R21EB009486-01; PMC2996919) [PDF] [Link]

36. Yang, X.; Shi, C.; Tong, R.; Qian, W.; Zhau, H. E.; Wang, R.; Zhu, G.; Cheng, J.; Yang, Y.; Cheng, T.; Henary, M.; Strekowski, L.; Chung, L.W.K. “Near Infrared Heptamethine Cyanine Dyes: 1. Cancer Imaging”, Clinical Cancer Research, 2010, 16, 2833-2844. (PMC2871283; NIH-MS188889) [PDF] [Link]

35. Tong, R.; Coyle, V.J.; Li, T.; Barger, A.M.; Fan, T.M.; Cheng, J. “Polylactide Nanoparticles Containing Stably-Incorporated Cyanine Dyes for In Vitro and In Vivo Imaging Applications”, Microscopy Research and Technique, 2010, 73, 901-909. [PDF] [Link]

34. Chaney, E.J.; Tang, L.; Tong, R.; Cheng, J.; Boppart, S.A. “Lymphatic Biodistribution of Polylactide Nanoparticles”, Molecular Imaging, 2010, 9, 153-162. (NSF-DMR07-48834; NIH-R21CA139329-01; PMC3699327; NIH-MS466991) [PDF] [Link]

33. Tong, R.; Cheng, J. “Controlled Synthesis of Camptothecin-Polylactide Conjugates Nanoconjugates “, Bioconjugate Chem., 2010, 21, 111-121. (NSF-DMR07-48834; NIH-1R21CA139329-01; PMC2809133; NIH-MS164604) [PDF] [Link]

32. Tong, R.; Yala, L.; Fan, T.M.; Cheng, J. “The formulation of aptamer-coated paclitaxel-polylactide nanoconjugates and their targeting to cancer cells”, Biomaterials, 2010, 31, 3043-3053. (NIH-1R21CA139329; NIH-1R21EB009486-01; NSF-DMR07-48834; PMC3222157; NIH-MS171453) [PDF] [Link]

2009

31. Lu, H.; Wang, J.; Lin, Y.; Cheng, J. “One-Pot Synthesis of Brush-Like Polymers via Integrated Ring-Opening Metathesis Polymerization and Polymerization of Amino Acid N-Carboxyanhydrides”, J. Am. Chem. Soc., 2009, 131, 13582-13583. (NSF-CHE0809420; NIH-1R21EB009486-01 ;PMC3222154; NIH-MS143879) [PDF] [SI] [Link] [Highlighted by Chemical and Engineering News]

30. Cao, Z.; Tong, R.; Xu, W.; Wong, G.W.L.; Cheng, J.; Lu, Y. “Reversible cell-specific delivery of chemotherapy drugs using aptamer-functionalized liposomes”, Angew. Chem. Int. Ed., 2009, 48, 6494-6498. (NSF-DMR0748834) [PDF] [SI] [Link]

29. Tong, R.; Cheng, J. “Ring-Opening Polymerization Mediated-Controlled Formulation of Polylactide Nanoparticles”, J. Am. Chem. Soc., 2009, 131, 4744-4754. (NSF-DMR0748834) [PDF] [SI] [Link]

28. Yigit, M.V.; Mishra, A.; Tong, R.; Cheng, J.; Wong, G.C.L.; Lu, Y. “Inorganic mercury detection and controlled release of chelating agents from ion-responsive PEG-liposomes”, Chem. Biol., 2009, 16, 937-942. (NSF-CTS0120978; NSF-DMR0117792; DE-FG02-08ER64568) [PDF] [SI] [Link]

27. Tong, R.; Tang, L.; Yala, L.; Cheng, J. “Controlled formulation of doxorubicin-polylactide nanoconjugates for cancer drug delivery”, IEEE. Eng Med Biol Soc. 2009, 1, 2400-2402. (NSF-DMR0748834) [PDF] [Link]

26. Tong, R.; Christian, D.A.; Tang, L.; Cabral, H.; Baker, J.R. Jr.; Kataoka, K.; Discher, D.; Cheng, J. “Nanopolymeric Therapeutics”, MRS Bulletin, 2009, 34, 422-431. (NSF-DMR0748834) [PDF] [Link]

2008

25. Lu, H.; Cheng, J. “N-Trimethylsilyl Amines for Controlled Ring-Opening Polymerization of Amino Acid N-Carboxyanhydrides and Facile End Group Functionalization of Polypeptides”, J. Am. Chem. Soc., 2008, 13012562–12563. (NSF-CHE0809420) [PDF][SI][Link]

24. Tong, R.; Cheng, J. “Paclitaxel-Initiated, Controlled Polymerization of Lactide for the Formulation of Polymeric Nanoparticulate Delivery Vehicles”, Angew. Chem. Int. Ed., 2008, 47, 4830-4834. (NSF-DMR07-48834) [PDF] [SI] [Link]

23. Lee, J.S.; Cheng, J.; Kim, K.Y. “Next Generation Nanosolutions for Cancer Treatment and Diagnosis”, Cancer and Chemotherapy Review, 2008, 3, 144-151.[PDF] [Link]

22. Teply, B.A.; Tong, R.; Jeong, S.Y.; Luther, G.; Sherifi, I.; Yim, C.H.; Khademhosseini, A.; Farokhzad, O.C.; Langer, R.; Cheng, J. “The Use of Charge-Coupled Polymeric Microparticles and Micromagnets for Modulation the Bioavailability of Orally Delivered Macromolecules”, Biomaterials, 2008, 29, 1216-1223. (PMC2268909; NIH-MS39924) [PDF] [Link]

2007

21. Lu, H.; Cheng, J. “Hexamethyldisilazane-Mediated Controlled Polymerization of α-Amino Acid-NCarboxyanhydrides”, J. Am. Chem. Soc., 2007, 129, 14114-14115[PDF] [SI] [Link]

20. Tong, R.; Cheng, J. “Anticancer Polymeric Nanomedicines”, Polymer Reviews, 2007, 47, 345-381. [PDF] [Link]

19. Karp, J.M.; Yeh, J.; Eng, G.; Fukuda, J.; Blumling, J.; Suh, K.Y.; Cheng, J.; Mahdavi, A.; Borenstein, J.; Langer, R.; Khademhosseini, A. “Controlling size, shape and homogeneity of embryoid bodies using poly(ethylene glycol) microwells”, Lab Chip, 2007, 7, 786-794. [PDF] [Link]

18. Cheng, J.; Teply, B.; Sherifi, I.; Sung, J.; Luther, G.; Gu, F.X.; Levy-Nissenbaum, E.; Langer, R.S.; Farokhzad, O.C. “Formulation of Functionalized PLGA-PEG Nanoparticles for In Vivo Targeted Drug Delivery”, Biomaterials, 2007, 28, 869-876. (PMC2925222; NIH-MS14538) [PDF][Link]

2006

17. Farokhzad, O.C.; Cheng, J.; Teply, B.A.; Sherifi, I.; Jon, S.; Kantoff, P.W.; Richie, J.P.; Langer, R. “Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo”, 

16. Cheng, J.; Zeidan, R.; Mishra, M.; Liu, A.; Pun, S.H.; Kulkarni, R.P.; Jensen, G.S.; Bellocq, N.; Davis, M.E. “Structure-Function Correlation of Chloroquine and Analogues as Transgene Expression Enhancers in Non-Viral Gene Delivery”, J. Med. Chem., 2006, 49, 6522-6531. [PDF] [SI] [Link]

15. Schluep, T.; Hwang, J.; Cheng, J.; Heidel, J.D.; Derek, W.; Bartlett, D.W.; Davis, M.E. “Preclinical Efficacy of the Camptothecin-Polymer Conjugate IT-101 in Multiple Cancer Models”, Clinical Cancer Research, 2006, 12, 1606-1614. [PDF] [Link]

14. Cheng, J.; Teply, B.; Yim, C.; Jeong, S.Y.; Sherifi, I.; Jon, S.; Khademhosseini, A.; Farokhzad, O.C.; Langer, R. “Magnetically Responsive Polymeric Microparticles for Oral Delivery of Protein Drugs”, Pharmaceutical Research, 2006, 23, 557-564. [PDF] [Link]

13. Fukuda, J.; Khademhosseini, A.; Yeh, J.; Eng, G.; Cheng, J.; Farokhzad, O.C.; Langer, R. “Micropatterned cell co-cultures using layer-by-layer deposition of extracellular matrix components”, Biomaterials, 2006, 27,1479-86. [PDF] [Link]

12. Schluep, T.; Cheng, J.; Khin, K.T.; Davis, M.E. “Pharmacokinetics and biodistribution of the camptothecin-polymer conjugate IT-101 in rats and tumor bearing mice”, Cancer Chemotherapy and Pharmacology, 2006, 57, 654-662. [PDF] [Link]

1996-2005

11. Cheng, J.; Yin, C.H.; Teply, B.A.; Ho, D.; Farokhzad, O.C.; Langer, R.S. “Magnetite-PLGA Microparticles for Oral Delivery of Insulin”, Mater. Res. Soc. Symp. Proc., 2005, 873, 581-586. (DuPont-MIT Alliance) [PDF] [Link]

10. Farokhzad, O.; Khademhosseini, A.; Jon, S.; Hermmann, A.; Cheng, J.; Chin, C.; Kiselyuk, A.; Eng, G.; Langer, R.S. “Microfluidic System for Studying the Interaction of Nanoparticles and Microparticles with Cells”, Analytical Chemistry, 2005, 77, 5453-5459.  [PDF] [Link]

9. Pun, S.H.; Tack, F.; Bellocq, N.C.; Cheng, J.; Grubbs, B.H.; Jensen, G.S.; Davis, M.E.; Brewster, M.; Janicot, M.; Janssens, B.; Floren, W.; Bakker, A.” Targeted delivery of RNA-cleaving DNA enzyme (DNAzyme) to tumor tissue by transferrin-modified, cyclodextrin-based particles”, Cancer biology & therapy ,2004, 3, 641-650. [PDF] [Link]

8. Cheng, J.; Khin, K.T.; Davis, M.E. “Antitumor Activity of (β-Cyclodextrin Polymer-Camptothecin Conjugates”, Molecular Pharmaceutics, 2004, 1, 183-193. [PDF] [Link]

7. Cheng, J.; Khin, K.T.; Jensen, G.S.; Liu, A.; Davis, M.E. “Synthesis of Linear, β-Cyclodextrin-Based Polymers and Their Camptothecin Conjugates”, Bioconjugate Chemistry, 2003, 14, 1007-1017. [PDF] [Link]

6. Cheng, J.; Deming, T.J., “Controlled Polymerization of Beta-lactams Using Metal-Amido Complexes: Synthesis of Block Copoly(β-peptides)”, J. Am. Chem. Soc., 2001, 123, 9457-9458. [PDF] [SI] [Link]

5. Cheng, J.; Deming, T.J. “Synthesis and Conformational Analysis of Optically Active Poly(β-peptides)”, Macromolecules, 2001, 34, 5169-5174. [PDF] [Link]

4. Cheng, J.; Ziller, J.W.; Deming, T.J. “Synthesis of Optically Active β-Amino Acid N-Carboxyanhydrides”, Organic Letters, 2000, 2, 1943-1946. [PDF] [SI] [Link]

3. Cheng, J.; Deming, T.J. “Screening of Optically Active Nickel Initiators for Enantioasymmetric Polymerization of α-Benzyl Glutamate-N-Carboxyanhydride”, Macromolecules, 1999, 32, 4745-4747. [PDF] [SI] [Link]

2. Smith, G.V.; Cheng, J.; Song, R. “New Enantioselective Heterogeneous Catalysts”, Catalysts Letters, 1997, 45, 73-78. [PDF] [Link]

1. Smith, G.V.; Cheng, J.; Song, R. “Enantioselective Hydrogenation of Prochiral C=C Bonds over Nobel Metal Catalysts Supported by β-Cyclodextrin Polymer”, Catalysts of Organic Reactions, 1996, 479-484. [PDF]

Chapters in Books

5. Yin, L.; Zheng, N., Cheng, J. “Highly Efficient siRNA Delivery Mediated by Cationic Helical Polypeptides and Polypeptide-Based Nanosystems”, siRNA Delivery Methods, 2016, 37-47. [PDF][Link]

4. Zheng, N.; Liu, Y.; Cheng, J. “Gene Delivery Method Using Photo-Responsive Poly(b-Amino Ester)”, Non-Viral Gene Delivery Vectors, 2016, 259-267. [PDF][Link]

3. Tong, R.; Tang, L.; Gabrielson, N.P.; Yin, Q.; Cheng, J. “Polymer-Drug Nanoconjugates”, Pharmaceutical Sciences Encyclopedia, book chapter in Nanoparticulate Drug Delivery Systems: Strategies, Technologies, and Applications, 2013. [PDF] [Link]

2. Tong, R.; Tang, L.; Cheng, J. “Development and Application of Anticancer Nanomedicine”, Nanostructure Science and Technology in “Multifunctional Nanoparticles for Drug Delivery Applications: Imaging, Targeting and Delivery”, Ed. by Svenson, S and Prudhomme, RK., 2012, 31-46. [PDF] [Link]

1. Cheng, J.; Pun, S.H. “Nanotechnology in Drug Delivery”, In “An Executive’s Guide to Nanotechnology”, Editor: Lynn Foster, Prentice Hall, 2005.

Patents

33. Cheng, J.; Ying, H. “Cyclic dynamic polyureas for polymeric urea processing”, US Patent App. 15/547,525, 2018.

32. Cheng, J.; Tong, R. “Particulate drug delivery methods”, US Patent 9,789,195, 2017.

31. Cheng, J.; Yin, L. “Nanoparticle mediated delivery of siRNA”, US Patent 9,617,544, 2017.

30. Cheng, J.; Zhang, Y. “Trigger-responsive chain-shattering polymers”, US Patent 9,593,197, 2017.

29. Cheng, J.; Gabrielson, N.; Yin, L. “Multiplexed supramolecular assemblies for non-viral delivery of genetic material”, US Patent 9,572,895, 2017.

28. Cheng, J.; Lu, H. “Stable helical ionic polypeptides”, US Patent 9,243,040, 2016.

27. Cheng, J.; Cai, K.; Ying, H. “Dynamic Urea Bonds with Fast Hydrolytic Kinetics for Polymers”, US 62/304,964, 2016.

26. Cheng, J.; Wang, H. “Trigger-Activatable Metabolic Sugar Precursors for Cancer-Selective Labeling and Targeting”, US 62/238,326, 2015.

25. Cheng, J.; Xiong, M.; Song, Z. “Antimicrobial Alpha-Helical Cationic Polypeptides”, US 62/185,345, 2015. (TF14094)

24. Cheng, J.; Tong, R. “Nanoconjugates and Nanoconjugate Formulations”, US Patent 9,295,651, 2016.

23. Cheng, J.; Cai, K. “Trigger Responsive Drug Conjugate for High Loading Nanoencapsulates”, US 62/120,821, 2015. (TF14168)

22. Cheng, J.; Tang, L. “Silica nanoparticle agent conjugates”, US Patent 9,028,880, 2015.

21. Cheng, J.; Ying, H.; Zhang, Y. “Dynamic urea bonds for polymers”, US 62/069, 385, 2014. (TF14085)

20. Cheng, J.; Ying, H. “Hydrolysable polymers with dynamic urea bonds”, US 62/069, 384, 2014. (TF14085)

19. Cheng, J.; Yen, J. “Enhanced Non-Viral Gene Delivery to Human Embryonic Stem Cells, Provision Patent Application”, US 62/029,964, 2014. (TF14100)

18. Rogers, J.A.; Kang, S.; Hwang, S.; Cheng, J.; Zhang, Z.; Ying, H. “Transient Electronic Devices Comprising Inorganic or Hybrid Inorganic and Organic substrates and encapsulates”,US 61/811,603.

17. Cheng, J.; Ying, H. “Dynamic urea bonds for reversible and self-healing polymers”, US 61/799,144, 2013. (TF 12136)

16. Cheng, J.; Yin, L. “Supramolecular Self-Assembled Nanoparticles Mediate Oral Delivery of Therapeutic TNF-a siRNA Against Systemic Inflammation”, US 61/810,983, 2013. (TF13054)

15. Cheng, J.; Zhang, Y. “Trigger-Responsive, Degradable Polymers”, US 61/649,205; US 61/648,715, 2012. (TF11176)

14. Cheng, J.; Lu, H. “Ionic Polypeptides with Unusual Helical Stability”, Converted US 61/418,269; WO PCT/US2011/062656, 2011. (TF10060)

13. Cheng, J.; Gabrielson,N.P. “Supramolecular Assembly for Non-Viral Gene Delivery”, US 61/371,618 2010; WO PCT/US2011/046791, 2011. (TF10042).

12. Cheng, J.; Tang, L. “Preparation of Degradable Silica-Drug Conjugated Nanoparticle with Monodisperse Particle Sizes”, US 61/418,230 2010; WO PCT/US2011/062548, 2011. (TF09149).

11. Cheng, J.; Tong, R. “Particulate Drug Delivery” PRO 60/892,834, 2007; US 12/041,529 2008; WO PCT/US2008/055590, 2008. (TF06188)

10. Chung, L.W.K.; Yang, X.; Cheng, J.; Tong, R. “Small molecule mediated cancer targeting and therapy” provisional application, 2008, US Patent App. 12/995,417.

9. Cheng, J.; Lu, H.” Controlled Ring-Opening Polymerization of NCA Using Organosilicon Reagents”, provisional application, 2008.

8. Cheng, J; Tong, R. “Particulate Drug Delivery”, PCT International Application, 2008; US Patent App. 12/041,529.

7. Farokhzad, O.; Cheng, J.; Teply, B.; Langer, R.S. “System for targeted delivery of therapeutics agents”, PCT international application, 2007, licensed by Bind Bioscience, Inc; US Patent     8,709,483, 2014; US Patent App. 14/322,738; US Patent 8,802,153.

6. Jon, S.; Farokhzad, O.C.; Langer, R.S.; Cheng, J. “Coated Controlled Release Polymer Particles as Efficient Oral Delivery Vehicles for Biopharmaceuticals”, PCT. International Application,     2006,  licensed by Bind Bioscience, Inc.

5. Bellocq, N.C.; Cheng, J; Pun, S.H.; Davis, M.E. “Carbohydrate-Modified Polymers, Compositions and Uses Related Thereto”, PCT. International Application, 2004, licensed by Insert     Therapeutics, Inc.

4. Cheng, J; Davis, M.E.; Khin, K.T. “Cyclodextrin-Based Polymers for Therapeutics Delivery”, PCT. International Application, 7,270,808, issued in 2007, licensed by Insert Therapeutics, Inc.

3. Pun, S.H.; Gonzalez, H.; Davis, M.E.; Bellocq, N.C.; Cheng, J. “Complexing agents for compositions containing inclusion complexes”, US 716, 6302, issued in 2007, licensed by Insert Therapeutics, Inc.

2. Pun, S.H.; Gonzalez, H.; Davis, M.E.; Bellocq, N.C.; Cheng, J. “Compositions containing inclusion complexes”, PCT. International Application, 701,8609, issued, licensed by Insert Therapeutics, Inc.

1. Deming. T.J.; Cheng, J. “Transition Metal Initiators for Controlled Poly(β-peptide) Synthesis from Beta-Lactam Monomers “, US Patent 6,818,732681,8732.