2015

     

    117. Tang, L.; Yin, Q.; Xu, Y.; Zhou, Q.; Cai, K.; Yen, J.; Dobrucki, L.W.; Cheng, J. " Bioorthogonal Oxime Ligation Mediated in Vivo Cancer Targeting", Chemical Science, First published online 02 Feb 2015 (NIHMS661301) [Link]

    116. Wang, H.; Xu, M.; Xiong, M.H.; Cheng, J. " Reduction-Responsive Dithiomaleimide-Based Nanomedicine with High Drug Loading and FRET-Indicated Drug Release ", Chemical Communicationsaccepted (NSF-DMR 1309525, 1DP2OD007246-01) [Link]

    115. Zheng, N.; Song, Z.; Liu, Y.; Zhang, R.; Zhang, R.; Yao, C.; Uckun, F.M.; Yin, L.; Cheng, J. "Redox-responsive, reversibly-crosslinked thiolated cationic helical polypeptides for efficient siRNA encapsulation and delivery", J. Controlled Releaseaccepted (NSF-CHE 1153122, 1DP2OD007246-01, 1R21EB013379-01)

    114. Uckun, F.M.; Ma, H.; Cheng, J.; Myers, D.E.; Qazi, S. "CD22deltaE12 as a molecular target for RNAi therapy", British Journal of Haematology, accepted (1DP2OD007246-01)

    113. Cai, K.; Yen, J.; Yin, Q.; Liu, Y.; Song, Z.; Lezmi, S.; Zhang, Y.; Yang, X.; Helferich, W.G.; Cheng, J. "Redox-Responsive Self-Assembled Chain-Shattering Polymeric Therapeutics", Biomaterials Scienceaccepted. (DMR 07-48834, NSF-DMR 1309525, 1DP2OD007246-01, 1R21CA152627; NIHMS664361) [Link]

    112. Gauthier, M.; Yin, Q.; Cheng, J.; O'Brien, W. "Design of albumin-coated microbubbles loaded with polylactide nanoparticles", J. Ultrasound Medicine, accepted (1DP2OD007246-01)

    111. Yin, L.; Chen, Y.; Zhang, Z.; Yin, Q.; Zheng, N.; Cheng, J. "Biodegradable Micelles Capable of Mannose-Mediated Targeted Drug Delivery to Cancer Cells", Macromolecular Rapid Communications, accepted (NSF-CHE 1153122, 1DP2OD007246-01, 1R21EB013379-01)

    110. Ma, L.; Baumgartner, R.; Zhang, Y.; Song, Z.; Cai, K.; Cheng, J. "UV-Responsive Degradable Polymers Derived from 1-(4-Aminophenyl) ethane-1, 2-diol", Journal of Polymer Science, Part A, 2015, accepted (Dow Chemical Company)

    109. Zhang, R.; Song, Z.; Yin, L.; Lu, H.; Gabrielson, N.P.; Cheng, J. "Ionic α-Helical Polypeptides towards Non-Viral Gene Delivery" WIREs Nanomedicine & Nanobiotechnolog, 2015, 7, 98-110. (NSF-CHE 1153122, 1DP2OD007246-01, 1R21EB013379-01; NIHMS631933) [PDF] [Link]

     

    2014

     

    108. Qu, Q.; Dong, L.; Louis, K.R.; Li, X.; Yang, H.; Sun, Q.; Crandall, S.R.; Tsang, S.; Zhou, J.; Cox, C.L.; Cheng, J.; Wang, F. "High-efficiency motor neuron differentiation from human pluripotent stem cells and the function of Islet-1", Nature Communications, 2014, 5, 3449. [PDF] [Link]

     

    107. Ying, H.; Zhang, Y.; Cheng, J. "Dynamic urea bond for the design of reversible and self-healing polymers", Nature Communications, 2014, 5, 3218. (NSF-CHE 1153122, 1DP2OD007246-01; NIHMS554614) [PDF][Link]

     

    106.  Tang, L.; Yang, X.; Yin, Q.; Cai, K.; Wang, H.; Chaudhury, I.; Yao, C.;Zhou, Q.; Kwon, M.; Hartman, J.A.; Dobrucki, I.T.; Dobrucki, L.W.; Borst,. L.B.; Lezmi, S.; Helferich, W.G.; Ferguson, A.L.; Fan, T.M.; Cheng, J. "Investigating the optimal size of anticancer nanomedicine", PNAS, 2014, 111, 15344-15349. (1DP2OD007246-01, 1R21CA152627; PMC4217425) [PDF[Link]

     

    105. Ying, H.; Cheng, J. "Hydrolysable Polyureas Bearing Hindered Urea Bonds", J. Am. Chem. Soc., 2014, 136, 16974-16977. (NSF-CHE 1153122, 1DP2OD007246-01) [PDF] [Link]

     

    104. Uckun, F.M.; Qazi, S.; Ma, H.; Yin, L.; Cheng, J. "A rationally designed nanoparticle for RNA interference therapy in B-lineage lymphoid malignancies", EBioMedicine, 2014, 1, 141-155.  (1DP2OD007246-01; PMC4292938, NIHMS644169) [PDF] [Link]

     

    103. Yin, L.; Huang, X.; Xu, H.; Zhang, Y.; Lam, J.; Cheng, J.; Rogers, JA. "Materials, Designs, and Operational Characteristics for Fully Biodegradable Primary Batteries", Advanced Materials, 2014, 26, 3879-3884. [PDF] [Link]

     

    102. Yen, J.; Yin, L.; Cheng, J. "Enhanced Non-Viral Gene Delivery to Human Embryonic Stem Cells via Small Molecule-Mediated Transient Alteration of Cell Structure",  Journal of Materials Chemistry B,  2014, 2, 8098-8105. (1DP2OD007246-01, 1R21EB013379-01, NSF-CHE 1153122; NIHMS632808) [PDF] [Link]

     

    101. Zheng, C.; Niu, L.; Pan, W.; Zhou, J.; Lv, H.; Cheng, J.; Liang, D.; "Long-term kinetics of DNA interacting with polycations", Polymer, 2014, 55, 2464-2471. [PDF] [Link]

     

    100. Myers, D.E.; Yiv, S.; Qazi, S.; Ma, H.; Cely, I.; Shahidzadeh, A.; Arellano, M.; Finestone, E.; Gaynon, P.; Termuhlen, A.; Cheng, J.; Uckun, F.,"CD19-antigen Q1 specific nanoscale liposomal formulation of a SYK Q2 P-site inhibitor causes apoptotic destruction of human B-precursor leukemia cells",  Integrative Biology, 2014, 6, 766-780. (1DP2OD007246-01) [PDF] [Link]

     

    99. Mahsan, K.; Chaudhury, I.; Cheng, J.; Safari, M.; Sadeghi, R.; Habibi-Rezaei, M.; Kokini, J.; "Immobilization of endo-inulinase on non-porous aminofunctionalized silica nanoparticles", Journal of Molecular Catalysis B: Enzymatic, 2014, 104, 48-55. [PDF] [Link]

     

    98. Deng, X.; Zheng, N.; Song, Z.; Yin, L.; Cheng, J. "Trigger-responsive, fast-degradable poly(-amino ester)s for enhanced DNA unpackaging and reduced toxicity", Biomaterials, 2014, 35, 5006-5015. (NSF-CHE 1153122, 1DP2OD007246-01, 1R21EB013379-01; NIHMS574051) [PDF] [Link]

     

    97. Song, Z.; Zheng, N.; Ba, X.; Yin, L.; Zhang, R.; Ma, L.; Cheng, J. "Polypeptides with Quaternary Phosphonium Side Chains: Synthesis, Characterization, and Cell-Penetrating Properties", Biomacromolecules, 2014, 15, 1491-1497. (NSF-CHE 1153122, 1DP2OD007246-01; PMC399387) [PDF] [Link]

     

    96. Zhang, Y.; Wang, R.; Hua, Y.; Baumgartner, R.; Cheng, J. "Trigger-Responsive Poly(β-amino ester) Hydrogels", ACS Macro Letters, 2014, 3, 693-697. (Dow Chemical Company) [PDF] [Link]

     

    95. Tong, R.; Tang, L.; Ma, L.; Tu, C.; Baumgartner, R.; Cheng, J. "Smart Chemistry in Polymeric Nanomedicines", Chemical Society Reviews, 2014, 43, 6982-7012. [PDF] [Link]

     

    94. Zhang, R.; Zheng, N.; Song, Z.; Yin, L.; Cheng, J.; "The effect of side-chain functionality and hydrophobicity on the gene delivery capabilities of cationic helical polypeptides", Biomaterials, 2014, 35, 3443-3454. (NSF-CHE 1153122, 1DP2OD007246-01, 1R21EB013379-01; NIHMS553359) [PDF] [Link]

     

    93. Uppada, S.B.; Erickson, T.; Wojdyla, L.; Moravec, D.N.; Song, Z.; Cheng, J.; Puri, N. "Novel delivery system for T-oligo using a nanocomplex formed with an alpha helical peptide for melanoma therapy", International Journal of Nanomedicine, 2014, 9, 43-53. (PMC3879016). [PDF] [Link]

     

    92. Lu, H.; Wang, J.; Song, Z.; Yin, L.; Zhang, Y.; Tang, H.; Tu, C.; Lin, Y.; Cheng, J. "Recent Advances in Amino Acid N-Carboxyanhydrides and Synthetic Polypeptides: Chemistry, Self-Assembly and Biological Applications", Chemical Communications, 2014, 50, 139-155. [PDF] [Link]

     

    91. Yin, Q.; Tong, R.; Yin, L.; Fan, T.M.; Cheng, J. "Anticancer Camptothecin-N-Poly(lactic acid) Nanoconjugates with Facile Hydrolysable Linker", Polymer Chemistry, 2014, 5, 1581-1585. (DMR 07-48834,  NSF-DMR 1309525, 1DP2OD007246-01, 1R21CA152627; NIHMS535764) [PDF] [Link].

     

    90. Zheng, N.; Yin, L.; Song, Z.; Ma, L.; Tang, H.; Gabrielson, N.P.; Lu, H.; Cheng, J. "Maximizing gene delivery efficiencies of cationic helical polypeptides via balanced membrane penetration and cellular targeting", Biomaterials, 2014, 35, 1302-1314. (1DP2OD007246-01, 1R21EB013379-01; NIHMS535394) [PDF] [Link]

     

    2013

     

    89. Zhang, Y.; Yin, Q.; Yin, L.; Ma, L.; Tang, L.; Cheng, J. "Chain-Shattering Polymeric Therapeutics with On-Demand Drug-Release Capability", Angew. Chem. Int. Ed., 2013, 52, 6435-6439. (Dow Chemical Company; PMC3800742, NIHMS502266) [PDF] [Link]

     

    88. Yin, L.; Song, Z.; Qu, Q.; Kim, K.H.; Zheng, N.; Yao, C.; Chaudhury, I.; Tang, H.; Gabrielson, N.P.; Uckun, F.M.; Cheng, J. "Supramolecular self-assembled nanoparticles mediate oral delivery of therapeutic TNF-α siRNA against systemic inflammation", Angew. Chem. Int. Ed., 2013, 52, 5757-5761. (NSF-CHE 1153122, 1DP2OD007246-01, 1R21EB013379-01; PMC3800743, NIHMS502261) [PDF] [Link]

     

    87. Yin, L.; Tang, H.; Kim, K.H.; Zheng, N.; Song, Z.; Gabrielson, N.P.; Lu, H.; Cheng, J. "Light-Responsive Helical Polypeptides Capable of Reducing Toxicity and Unpacking DNA: Toward Nonviral Gene Delivery", Angew. Chem. Int. Ed., 2013, 52, 9182-9186. (NSF-CHE 1153122, 1DP2OD007246-01, 1R21EB013379-01; PMC4232450, NIHMS520820) [PDF] [Link]

     

    86. Yin, Q.; Yap, F.Y.; Yin, L.; Ma, L.; Zhou, Q.; Dobrucki, L.W.; Fan, T.M.; Gaba, R.C.; Cheng, J. "Poly(iohexol) Nanoparticles As Constrast Agents for In Vivo X-ray Computed Tomography Imaging", J. Am. Chem. Soc., 2013, 135, 13620-13623. (1DP2OD007246-01, 1R21CA152627; PMC4232444, NIHMS522439) [PDF] [Link]

     

    85. Wang, J.; Xia, H.; Zhang, Y.; Lu, H.; Kamat, R.; Dobrynin, A.V.; Cheng, J.; Lin, Y. "Nucleation-Controlled Polymerization of Nanoparticles into Supramolecular Structures", J. Am. Chem. Soc., 2013, 135, 11417-11420. (1R21EB013379-01, NSF-CHE 1153122) [PDF] [Link] [Cover]

     

    84. Tang, H.; Yin, L.; Kim, K.H.; Cheng, J. "Helical Poly(arginine) Mimics with Superior Cell-Penetrating and Molecular Transporting Properties", Chemical Science, 2013, 4, 3839-3844. (NSF-CHE 1153122, 1DP2OD007246-01, 1R21EB013379-01; PMC4232443, NIHMS516191) [PDF] [Link]

     

    83. Yin, L.; Song, Z.; Kim, K.H.; Zheng, N.; Gabrielson, N.P.; Cheng, J. "Non-Viral Gene Delivery via Membrane-Penetrating, Mannose-Targeting Supramolecular Self-Assembled Nanocomplexes", Advanced Materials, 2013, 25, 3063-3070. (NSF-CHE 1153122, 1DP2OD007246-01, 1R21EB013379-01; PMC3757134, NIHMS499301) [PDF] [Link] [Cover]

     

    82. Xing, H.; Tang, L.; Yang, X.; Hwang, K.; Wang, W.; Yin, Q.; Wong, N.Y.; Dobrucki, L.W.; Yasui, N.; Katzenellenbogen, J.A.; Helferich, W.G.; Cheng, J.; Lu, Y. "Selective delivery of an anticancer drug with aptamer-functionalized liposomes to breast cancer cells in vitro and in vivo", Journal of Materials Chemistry B, 2013, 1, 5288-5297. (1DP2OD007246-01, 1R21CA152627; PMC3800741, NIHMS514388) [PDF] [Link

     

    81. Tang, L.; Cheng, J. "Nonporous Silica Nanoparticles for Nanomedicine Application", Nano Today, 2013, 8, 290-312. (1DP2OD007246-01, 1R21CA152627; PMC3757135, NIHMS481146) [PDF] [Link]

     

    80. Yen, J.; Zhang, Y.; Gabrielson, N.P.; Yin, L.; Guan, L.; Chaudhury, I.; Lu, L.; Wang, F.; Cheng, J. "Cationic, helical polypeptide-based gene delivery for IMR-90 fibroblasts and human embryonic stem cell",  Biomaterials Science, 2013, 1, 719-727. (1DP2OD007246-01, 1R21EB013379-01, NSF-CHE 1153122;  PMC3757133, NIHMS464545) [PDF] [Link]
     

    79. Song, Z.; Zhang, R.; Lu, H.; Gabrielson, NP; Yin, L.; Ponnusamy, E.; Cheng, J. "Synthesis and Biomedical Applications of Polyamino Acids", Materials Matters, 2013, 8, 78-84. (NSF-CHE 1153122, 1DP2OD007246-01, 1R21EB013379-01) [PDF]

     

    78. Wang, H.; Tang, L.; Tu, C.; Song, Z.; Yin, Q.; Yin, L.; Zhang, Z.; Cheng, J. "Redox-Responsive, Core-Cross-Linked Micelles Capable of On-Demand, Concurrent Drug Release and Structure Disassembly", Biomacromolecules, 2013, 14, 3706-3712. (1DP2OD007246-01, NSF-DMR 1309525; PMC4232441, NIHMS523142) [PDF] [Link]

     

    77. Yin, Q.; Tong, R.; Xu, Y.; Baek, K.; Dobrucki, L.W.; Fan, T.M.; Cheng, J. "Drug-Initiated Ring-Opening Polymerization of O-Carboxyanhydrides for the Preparation of Anticancer Drug-Poly(O-Carboxyanhydride) Nanoconjugates", Biomacromolecules, 2013, 14, 920-929. (DMR 07-48834, 1DP2OD007246-01, 1R21CA152627; PMC3671392, NIHMS450799) [PDF] [Link]

     

    76. Cameron J.A.; Milner D.J.; Lee J.S.; Cheng J;  Fang, N.X.; Jasiuk, I.M. "Employing the biology of successful fracture repair to heal critical size bone defects", Current Topics in Microbiology and Immunology, 2013, 367, 113-132. [PDF] [Link]

     

    75. Uckun, F.M.; Qazi, S.; Cely, I.; Sahin, K.; Shahidzadeh, A.; Ozercan, I.; Yin, Q.; Gaynon, P.; Termuhlen, A.; Cheng, J.; Yiv, S. "Nanoscale liposomal formulation of a SYK P-site inhibitor against B-precursor leukemia",  Blood, 2013, 121, 4348-4354. (1DP2OD007246-01; PMC3663427) [PDF] [Link]

     

    74. Zhang, Y.; Yin, Q.; Lu, H.; Xia, H.; Lin, Y.; Cheng, J. "PEG-Polypeptide Dual Brush Block Copolymers: Synthesis and Application in Nanoparticle Surface PEGylation", ACS Macro Letters, 2013, 2, 809-813.(NSF-CHE 1153122, 1DP2OD007246-01; PMC3804265, NIHMS518036) [PDF] [Link] 

     

    73. Zhang, R.; Lu, H.; Gabrielson, N.P.; Yin, L.; Cheng, J. "Cationic α-Helical Polypeptide Template for Nonviral Gene Delivery", SurFACTS in Biomaterials, 2013, 18, 2. (1DP2OD007246-01, 1R21EB013379-01) [PDF]

     

    72. Mirshafiee, V.; Mahmoudi, M.; Lou, K.; Cheng, J.; Kraft, M.L. "Protein Corona Significantly Reduces Active Targeting Yield", Chemical Communications, 2013, 49, 2557-2559. (1R21CA152627; PMC3671387, NIHMS447802) [PDF] [Link]

     

    71. Tang L., Gabrielson N.P., Uckun F.M., Fan T.M., Cheng J. "Size-dependent tumor penetration and in vivo efficacy of monodisperse drug-silica nanoconjugates", Molecular Pharmaceuticals. 2013, 10, 883-892. (1DP2OD007246-01, 1R21CA152627; PMC3697826, NIHMS445569) [PDF] [Link]

     

    70. Tong, R.; Tang, L.; Gabrielson, N.P.; Yin, Q.; Cheng,J. "Polymer-Drug Nanoconjugates", book chapter in Nanoparticulate Drug Delivery Systems: Strategies, Technologies, and Applications", Ed. Y. Yeo, Wiley, April 2013. [Link]

     

    69. Yin, L.; Song, Z.; Kim, H.K.; Zheng, N.; Tang, H.; Lu, H.; Gabrielson, N.P.; Cheng, J. "Reconfiguring the architectures of cationic helical polypeptides to control non-viral gene delivery", Biomaterials, 2013, 34, 2340-2349. (NSF-CHE 1153122, 1DP2OD007246-01, 1R21EB013379-01) [PDF] [Link]

     

    68.  Zhang, Z.; Yin, L.; Tu, C.; Song, Z.; Zhang, Y.; Xu, Y.; Tong, R.; Zhou, Q.; Ren, J.; Cheng, J. "Redox-Responsive, Core Cross-Linked Polyester Micelles", ACS Macro Lett., 2013, 2, 40-44. (1DP2OD007246-01, 1R21EB013379-01, NSF-CHE 1153122, DMR 07-48834; PMC3606897, NIHMS431405) [PDF] [Link]

     

    67. Zhang, Y.; Ma, L.; Deng, X.; Cheng, J. "Trigger-Responsive Chain-Shattering Polymers", Polymer Chemistry, 2013, 4, 224-228. (Dow Chemical Company) [PDF] [Link]

     

    2012

     

    66. Tang, L.; Yang, X.; Dobrucki, L.W.; Chaudhury, I.; Yin, Q.; Yao, C.; Lezmi, S.; Helferich, W.G.; Fan, T.M.; Cheng, J.  "Aptamer-functionalized, ultra-small, monodisperse silica nanoconjugate for targeted dual-modal imaging of lymph nodes with metastatic tumors", Angew. Chem., 2012, 124, 12893-12898. (1DP2OD007246-01, 1R21CA152627; NIHMS512609) [PDF] [Link] 

     

    65. Gabrielson, N.P.; Lu, H.; Yin, L.; Li, D.; Wang, F.; Cheng, J. "Reactive and Bioactive Cationic a-Helical Polypeptide Template for Non-Viral Gene Delivery", Angew. Chem. Int. Ed., 2012, 51, 1143-1147. (1DP2OD007246-01, 1R21CA152627; PMC3555134, NIHMS400098) [PDF] [Link]

     

    64. Tong, R.; Cheng, J. "Zinc complex mediated regioselective O-acylation of therapeutic agents", Chemical Science, 2012, 3, 2234-2239. [PDF] [Link]

     

    63. Tong, R.; Gabrielson, N.P.; Fan, T.M.; Cheng, J. "Polymeric Nanomedicine Based on Poly(lactide) and Poly(lactic-co-glycolide)", Current Opinion in Solid State & Materials Science, 2012, 16, 323-332. (PMC3728009, NIHMS439167) [PDF] [Link] 

     

    62. Tong, R.; Tang, L.; Cheng, J., "Development and Application of Anticancer Nanomedicine", Nanostructure Science and Technology in "Multifunctional Nanoparticles for Drug Delivery Applications: Imaging, Targeting and Delivery", Ed. by Svenson, S and Prudhomme, RK., 2012, 31-46. [PDF] [Link]

     

    61. Cely, I.; Yiv, S.;Yin, Q.; Shahidzadeh, A.; Tang, L.; Cheng, J.; Uckun, F.M. "Targeting Mantle Cell Lymphoma with Anti-SYK Nanoparticles", J. Anal. Oncol., 2012, 1, 1-9. (1DP2OD007246-01; PMC3668349, NIHMS406536) [PDF] [Link]

     

    60. Li, L.; Yin, Q.; Cheng, J., Lu, Y. "Polyvalent Mesoporous Silica Nanoparticle-Aptamer Bioconjugates Target Breast Cancer Cells", Advanced Healthcare Materials, 2012, 1, 567-572. (1DP2OD007246-01, 1R21CA152627) [PDF] [Link]

     

    59. Gabrielson, N. P.; Lu, H.; Yin, L.; Kim, K.H.; Cheng, J. "A Cell-Penetrating Helical Polymer for siRNA Delivery to Mammalian Cells", Molecular Therapy, 2012, 20, 1599-1609. (1R21EB013379-01, 1DP2OD007246-01; PMC3412491) [PDF] [Link]

     

    58. Tang, L.; Azzi, J.;  Kwon, M.; Mounayar, M.; Tong, R.; Yin, Q.; Moore, R.; Skartsis, N.; Fan, T.M.;  Abdi, R.; Cheng, J. "Immunosuppressive Activity of Size-Controlled PEG-PLGA Nanoparticles Containing Encapsulated Cyclosporine A",  Journal of Transplantation, 2012, 2012, 896141. (1DP2OD007246-01, 1R21CA152627; PMC3321582) [PDF] [Link]

     

    57. Tang, H.; Yin, L.; Lu, H.; Cheng, J. "Water-Soluble Poly(L-serine)s with Elongated and Charged Side-Chains: Synthesis, Conformations and Cell-Penetrating Properties", Biomacromolecules, 2012, 13, 2609-2615. (1R21EB013379-01, 1DP2OD007246-01; PMC3555145, NIHMS401030) [PDF] [Link]

     

    56. Tang, L.; Fan, T.M.; Borst, L.B.; Cheng, J. "Synthesis and Biological Response of Size-Specific, Monodisperse Drug-Silica Nanoconjugates", ACS Nano., 2012, 6, 3954-3966. (1DP2OD007246-01, 1R21CA152627; PMC3555148, NIHMS372943) [PDF] [Link]

     

    55.  Lu, Y.; Yin, L.; Zhang, Y.; Zhang, Z.; Xu, Y.; Tong, R.; Cheng, J. "Synthesis of Water-Soluble Poly(α-hydroxy acids) from Living Ring-Opening Polymerization of O-Benzyl-L-serine Carboxyanhydrides", ACS Macro Letters, 2012, 1, 441-444. (DMR 07-48834,  1DP2OD007246-01, 1R21EB013379-01; PMC3555137, NIHMS363858) [PDF] [Link]

     

    54. Tong, R.; Cheng, J. "Drug-Initiated, Controlled Ring-Opening Polymerization for the Synthesis of Polymer-Drug Conjugates", Macromolecules, 2012, 45, 2225-2232. (1DP2OD007246-01; PMC3555138, NIHMS359696) [PDF] [Link]

     

    53. Zhang, Z.; Yin, L.; Xu, Y.; Ren, J.; Cheng, J. "Facile Functionalization of Polyesters through Thiol-yne Chemistry for the Design of Degradable, Cell‒Penetrating and Gene Delivery Dual‒Functional Agents",  Biomacromolecules, 2012, 13, 3456-3462. (1R21EB013379-01, 1DP2OD007246-01, NSF-CHE 1153122; PMC3606898, NIHMS417829) [PDF] [Link] 

     

    52. Chen, K.; Tang, L.; Garcia, M.A.; Wang, H.; Lu, H.; Lin,  W.; Hou, S.; Yin, Q.; Shen, C.K.F.; Cheng, J.; Tseng, H.R. "The therapeutic efficacy of camptothecin-encapsulated supramolecular nanoparticles", Biomaterials, 2012, 33, 1162-1169. (1R21CA152627; PMC3786683, NIHMS333953) [PDF] [Link]

     

    2011

     

    51. Lu, H.; Wang, J.; Bai, Y.; Lang, J.W.; Liu, S.; Lin, Y.; Cheng, J. "Ionic Polypeptides with Unusual Helical Stability", Nature Communications, 2011, 2, 206. (DMR 07-48834, 1DP2OD007246-01) [PDF] [Link]

     

    50. Mishra, A.;  Lai, G.H.; Schmidt, N.W.; Sun, V.Z.; Rodriguez, A.R., Tong, R.; Tang, L.; Cheng, J.; Deming, T.J.;  Kamei, D.T.; Wong, G.C.L. "Translocation of HIV TAT peptide and analogues induced by multiplexed membrane and cytoskeletal interactions", PNAS, 2011, 108, 16883-16888. (PMC3193208) [PDF] [Link]

     

    49. Wang, J.; Lu, H.; Kamat, R.; Pingali, S.V.; Urban, V.S.; Cheng, J.; Lin, Y. "Supramolecular Polymerization from Polypeptide-Grafted Comb Polymers", J. Am. Chem. Soc., 2011, 133, 12906-12909. [PDF] [Link] 

     

    48. Bai, Y.; Lu, H.; Ponnusamy, E.; Cheng, J. "Synthesis of Hybrid Block Copolymers via Integrated Ring-Opening Metathesis Polymerization and Polymerization of NCA", Chemical Communications, 2011, 47, 10830-10832. (1DP2OD007246-01) [PDF] [Link]

     

    47. Zhang, Y.; Lu, H.; Yao, L.; Cheng, J. "Water-Soluble Polypeptides with Elongated, Charged Side Chains Adopt Ultrastable Helical Conformations", Macromolecules, 2011, 44, 6641-6644. (1DP2OD007246-01; PMC3204311, NIHMS317340) [PDF] [Link]

     

    46. Lu, H.; Bai, Y.; Wang, J.; Gabrielson, N.; Wang, F.; Lin, Y.; Cheng, J. "Ring-Opening Polymerization of g-(4-Vinylbenzyl)-L-Glutamate N-Carboxyanhydride for the Synthesis of Functional Polypeptides", Macromolecules, 2011, 44, 6237-6240. (1DP2OD007246-01; PMC3222942, NIHMS312521) [PDF] [Link] [Cover]

     

    45. Cheng, J.; Deming, TJ, "Synthesis of Polypeptides by Ring-Opening Polymerization of α-Amino Acid N-Carboxyanhydrides." Top Curr. Chem. 2011, 310, 1-26. [PDF] [Link]

     

    44. Wang, J.; Lu, H.; Ren, Y.; Zhang, Y.; Morton, M.; Cheng, J.; Lin, Y. "Interrupted Helical Structure of Grafted Polypeptides in Brush-Like Macromolecules", Macromolecules, 2011, 44, 8699-8708. (1R21EB013379-01) [PDF] [Link]  

     

    43. Tong, R., Tang, L., Yin, Q., Cheng, J. "Drug-polyester conjugated nanoparticles for cancer drug delivery", IEEE. Eng. Med. Biol. Soc., 2011, 3, 8337-8339. [PDF] [Link] 

     

    42. Li, D.; Zhou, J.; Chowdhury, F.; Cheng, J.; Wang, N.; Wang, F. "Role of mechanical factors in fate decisions of stem cells." Regenerative Medicine, 2011, 6, 229-240. (PMC3128460, NIHMS303388) [PDF] [Link]

     

    2010

     

    41. Chan, J.M.; Zhang, L. F.; Tong, R.; Ghosh, D.; Gao, W.; Liao, G.; Yuet, K.; Gray, D.; Rhee, J.W.; Cheng, J.; Golomb, G.; Libby, P; Langer, R.; Farokhzad, O. "Spatiotemporal Controlled Delivery of Nanoparticles to Injured Vasculature", PNAS, 2010, 107, 2213-2218. (PMC2836709) [PDF]

     

    40. Li, C.; Zhang, Y.; Hu, J..; Cheng, J.; Liu, S. "Reversible Three-State Switching of Multicolor Fluorescence Emission via Multiple Stimuli-Modulated FRET Processes within Thermoresponsive Polymeric Micelles", Angew. Chem. Int. Ed., 2010, 49, 5120-5124. [PDF].

     

    39. Azzi J, Tang L, Moore R, Tong R, El Haddad N, Akiyoshi T, Mfarrej B, Yang S, Jurewicz M, Ichimura T, Lindeman N, Cheng J, Abdi R. "Polylactide-Cyclosporin A Nanoparticles for Targeted Immunosuppression", FASEB J., 2010, 24, 3927-3938. (PMC2996919)[PDF].

     

    38. Yang, X.; Shi, C.; Tong, R.; Qian, W.; Zhau, H. E.; Wang, R.; Zhu, G., Cheng, J. Yang, Y.; Cheng, T.; Henary, M.; Strekowski, L.; Chung, L.W.K. "Near Infrared Heptamethine Cyanine Dyes: 1. Cancer Imaging",  Clinical Cancer Research, 2010, 16, 2833-2844. (PMC2871283, NIHMS188889) [PDF]

     

    37. Gabrielson, N.; Xu, Y.; Cheng, J. "Multiplexed supramolecular self-assembly for non-viral gene delivery", Biomaterials, 2010, 31, 9117-9127. (PMC2952339, NIHMS229754) [PDF] 

     

    36. Tong, R.; Coyle, V.J.; Li, T.; Barger, A.M.; Fan, T.M.; Cheng, J. "Polylactide Nanoparticles Containing Stably-Incorporated Cyanine Dyes for In Vitro and In Vivo Imaging Applications", Microscopy Research and Technique, 2010, 73, 901-909. [PDF] [Journal Cover].

     

    35. Chaney, E.J.; Tang, L.; Tong, R.; Cheng, J.; Boppart, S.A. "Lymphatic Biodistribution of Polylactide Nanoparticles", Molecular Imaging, 2010, 9, 153-162. (DMR 07-48834; PMC3699327, NIHMS466991) [PDF]

     

    34. Tong, R.; Cheng, J. "Controlled Synthesis of Camptothecin-Polylactide Conjugates", Bioconjugate Chem., 2010, 21, 111-121. (PMC2809133, NIHMS164604) [PDF].

     

    33. Tong, R.; Yala, L.; Fan, T.M.; Cheng, J. "The formulation of aptamer-coated paclitaxel-polylactide nanoconjugates and their targeting to cancer cells", Biomaterials, 2010, 31, 3043-3053 (PMC3222157, NIHMS171453) [PDF].

     

    2009

     

    32. Lu, H.; Wang, J.; Lin, Y.; Cheng, J. "One-Pot Synthesis of Brush-Like Polymers via Integrated Ring-Opening Metathesis Polymerization and Polymerization of Amino Acid N-Carboxyanhydrides", J. Am. Chem. Soc., 2009, 131, 13582-13583 (PMC3222154, NIHMS143879) [PDF] Highlighted by Chemical and Engineering News.

     

    31. Cao, Z.; Tong, R.; Xu, W.; Wong, G.W.L.; Cheng, J.; Lu, Y. "Reversible cell-specific delivery of chemotherapy drugs using aptamer-functionalized liposomes", Angew. Chem. Int. Ed., 2009, 48, 6494-6498.[PDF]

     

    30. Tong, R.; Cheng, J. "Ring-Opening Polymerization Mediated-Controlled Formulation of Polylactide Nanoparticles", J. Am. Chem. Soc., 2009, 131, 4744-4754. [PDF]

     

    29. Tong, R.; Christian, D.A.; Tang, L.; Cabral, H.; Baker, J.R. Jr.; Kataoka, K.; Discher, D.; Cheng, J. "Nanopolymeric Therapeutics", MRS Bulletin, 2009, 34, 422-431. [PDF]

     

    28. Tong, R.; Tang, L.; Yala, L.; Cheng, J. "Controlled formulation of doxorubicin-polylactide nanoconjugates for cancer drug delivery", IEEE. Eng Med Biol Soc. 2009, 1, 2400-2402. [PDF]

     

    27. Yigit, M.V.; Mishra, A.; Tong, R.; Cheng, J.; Wong, G.C.L.; Lu, Y.  "Inorganic mercury detection and controlled release of chelating agents from ion-responsive PEG-liposomes", Chem. Biol., 2009, 16, 937-942. [PDF] 

     

    2008

     

    26. Lu, H.; Cheng, J. "Controlled Ring-Opening Polymerization of Amino Acid N-Carboxyanhydrides and Facile End Group Functionalization of Polypeptides", J. Am. Chem. Soc., 2008, 130, 12562-12563. [PDF]

     

    25. Tong, R.; Cheng, J. "Paclitaxel-Initiated, Controlled Polymerization of Lactide for the Formulation of  Polymeric Nanoparticulate Delivery Vehicles", Angew. Chem. Int. Ed., 2008, 47, 4830-4834. [PDF]. 

     

    24. Lee, J.S.; Cheng, J.; Kim, K.Y. "Next Generation Nanosolutions for Cancer Treatment and Diagnosis", Cancer and Chemotherapy Review, 2008, 3, 144-151.[PDF]

     

    23. Teply, B.A.; Tong, R.; Jeong, S.Y.;  Luther,G.; Sherifi, I.; Yim, C.H.; Khademhosseini, A.;  Farokhzad, O.C.; Langer R.; Cheng J. "The Use of Charge-Coupled Polymeric Microparticles and Micromagnets for  Modulation the Bioavailability of Orally Delivered Macromolecules", Biomaterials, 2008, 29, 1216-1223. (PMC2268909, NIHMS39924) [PDF]

     

    2007

     

    22. Lu, H.; Cheng, J. "Hexamethyldisilazane-Mediated Controlled Polymerization of α-Amino Acid-NCarboxyanhydrides", J. Am. Chem. Soc., 2007, 129, 14114-14115.[PDF]

     

    21. Tong, R.; Cheng, J. "Anticancer Polymeric Nanomedicines", Polymer Reviews, 2007, 47, 345-381. [PDF]

     

    20. Karp, J.M., Yeh, J.; Eng, G.; Fukuda, J.; Blumling, J.; Suh, K.Y.; Cheng, J.; Mahdavi, A.; Jeffrey Borenstein, J.; Langer, R.; Khademhosseini, A.  "Controlling size, shape and homogeneity of embryoid bodies using poly(ethylene glycol) microwells", Lab Chip, 2007, 7, 786 - 794. [PDF]

     

    19. Cheng, J.; Teply, B.; Sherifi, I.; Sung, J.; Luther. G.; Gu, F.X.; Levy-Nissenbaum, E.; Langer, R. Farokhzad, O.C. "Formulation of Functionalized PLGA-PEG Nanoparticles for In Vivo Targeted Drug Delivery", Biomaterials, 2007, 28, 869-876. (PMC2925222, NIHMS14538) [PDF] 

     

    2006

     

    18. Farokhzad, O.C.; Cheng, J. (co-first author); Teply, B.A.; Sherifi, I.; Khademhosseini, A.; Langer, R. "In vivo prostate tumor reduction after single administration of docetaxel encapsulated nanoparticle-aptamer bioconjugates", PNAS, 2006, 103, 6315-6320.  [PDF]

     

    17. Cheng, J.; Zeidan, R.; Mishra, M.; Liu, A.; Pun, S.H.; Kulkarni, R.P.; Jensen, G.S.;  Bellocq, N.;  Davis, M.E. Structure-Function Correlation of Chloroquine and Analogues as Transgene Expression Enhancers in Non-Viral Gene Delivery. J. Med. Chem., 2006, 49, 6522-6531.[PDF]

     

    16. Schluep T.; Hwang J.; Cheng J.; Heidel, J.D.; Derek W.; Bartlett, D.W.; Davis, M.E. "Preclinical Efficacy of the Camptothecin-Polymer Conjugate IT-101 in Multiple Cancer Models." Clinical Cancer Research, 2006, 12, 1606-1614. [PDF]

     

    15. Cheng, J.; Teply, B.; Yim, C.; Jeong, S.Y.; Sherifi, I.; Jon, S.; Khademhosseini, A.; Farokhzad, O.C.; Langer, R.S. "Magnetically Responsive Polymeric Microparticles for Oral Delivery of Protein Drugs", Pharmaceutical Research, 2006, 23, 557-564. [PDF]

     

    14. Fukuda, J.; Khademhosseini, A.; Yeh, J.; Eng, G.; Cheng, J.; Farokhzad, O.C.; Langer, R.S. "Micropatterned cell co-cultures using layer-by-layer deposition of extracellular matrix components", Biomaterials, 2006, 27,1479-86. [PDF]

     

    13. Schluep, T.; Cheng, J.; Khin, K.T.; Davis, M.E. "Pharmacokinetics and biodistribution of the camptothecin-polymer conjugate IT-101 in rats and tumor bearing mice", Cancer Chemotherapy and Pharmacology, 2006, 57, 654-662. [PDF]

     

    1996-2005

     

    12. Cheng, J.; Yin, C.H.; Teply, B.A.; Ho, D.; Farokhzad, O.C.; Langer, R.S. "Magnetite-PLGA Microparticles for Oral Delivery of Insulin", Mater. Res. Soc. Symp. Proc., 2005, 873E, K581-K586. [PDF]

     

    11. Cheng, J.; Pun, S.H. "Nanotechnology in Drug Delivery", In "An Executive's Guide to Nanotechnology", Editor: Lynn Foster, Prentice Hall, 2005.

     

    10. Farokhzad, O.; Khademhosseini, A.; Jon, S.; Hermmann, A.; Cheng, J.; Chin, C.; Kiselyuk, A.; Eng, G.; Langer, R. "Microfluidic System for Studying the Interaction of Nanoparticles and Microparticles with Cells" Analytical Chemistry, 2005, 77, 5453-5459. (PMC1458875) [PDF] [Link]

     

    9. Pun, S.H.; Bellocq, N.C.; Cheng, J.; Grubbs, B.H.; Jensen, G.S.; Davis, M.E.; Tack, F.; Brewster, M.; Janicot, M.; Janssens, B.; Floren, W.; Bakker, A. "Biodistribution of RNA-cleaving DNA Enzyme (DNAzyme) to Tumor Tissue by Transferrin-Modified, Cyclodextrin-Based Particles", Cancer Biology and Therapy, 2004, 3, 641-650. [PDF]

     

    8. Cheng, J.; Khin, K.T.; Davis, M.E. "Antitumor Activity of (β-Cyclodextrin Polymer-Camptothecin Conjugates", Molecular Pharmaceutics, 2004, 1, 183-193. [PDF]

     

    7. Cheng, J.; Khin, K.T.; Jensen, G.S.; Liu, A.; Davis, M.E. "Synthesis of Linear, β-Cyclodextrin-Based Polymers and Their Camptothecin Conjugates", Bioconjugate Chemistry, 2003, 14, 1007-1017. [PDF]

     

    6. Cheng, J.; Deming, T.J., "Controlled Polymerization of Beta-lactams Using Metal-Amido Complexes: Synthesis of Block Copoly(β-peptides)", J. Am. Chem. Soc., 2001, 123, 9457-9458. [PDF]

     

    5. Cheng, J.; Deming, T.J. "Synthesis and Conformational Analysis of Optically Active Poly(β-peptides)", Macromolecules, 2001, 34, 5169-5174. [PDF]

     

    4. Cheng, J.; Ziller, J.W.; Deming, T.J. "Synthesis of Optically Active β-Amino Acid N-Carboxyanhydrides". Organic Letters, 2000, 2, 1943-1946. [PDF]

     

    3. Cheng, J.; Deming, T.J. "Screening of Optically Active Nickel Initiators for Enantioasymmetric Polymerization of α-Benzyl Glutamate-N-Carboxyanhydride". Macromolecules, 1999, 32, 4745-4747. [PDF]

     

    2. Smith, G.V.; Cheng, J.; Song, R. "New Enantioselective Heterogeneous Catalysts", Catalysts Letters, 1997, 45, 73-78.

     

    1. Smith, G.V.; Cheng, J.; Song, R. "Enantioselective Hydrogenation of Prochiral C=C Bonds over Nobel Metal Catalysts Supported by β-Cyclodextrin Polymer", Catalysts of Organic Reactions, 1996, 479-484.

     

     

    Patents

    18. Cheng, J.; Ying, H. "Dynamic urea bonds for reversible and self-healing polymers", 61/799,144, 3/14/2013

    17. Cheng, J.; Yin, L. "Supramolecular Self-Assembled Nanoparticles Mediate Oral Delivery of Therapeutic TNF-a siRNA Against Systemic Inflammation" US 61/810,983, 2013. (TF13054)

    16. Cheng, J.; Zhang, Y. "Trigger-Responsive, Degradable Polymers" US 61/649,205, US 61/648,715, 2012. (TF11176)

    15. Cheng, J.; Lu, H. "Ionic Polypeptides with Unusual Helical Stability" Converted US 61/418,269, WO PCT/US2011/062656, 2011. (TF10060)

    14. Cheng, J.; Gabrielson. "Supramolecular Assembly for Non-Viral Gene Delivery" US 61/371,618 2010, WO PCT/US2011/046791, 2011 (TF10042).

    13. Cheng, J.; Tong, R. "Aptamer-Coated Paclitaxel-Polyactide Nanoconjugates: Formulation & Cancer Targeting" US 61/289,893, WO PCT/US2010/062030 2010 (TF09151).

    12. Cheng, J.; Tang, L. "Preparation of Degradable Silica-Drug Conjugated Nanoparticle with Monodisperse Particle Sizes" US 61/418,230 2010, WO PCT/US2011/062548, 2011 (TF09149).

    11.  Cheng, J.; Tong, R. "Particulate Drug Delivery" PRO 60/892,834, 2007; US 12/041,529 2008; WO PCT/US2008/055590 2008 (TF06188)

    10. Chung, L.W.K.; Yang, X.; Cheng, J.; Tong, R. "Small molecule mediated cancer targeting and therapy" provisional application, 2008

    9. Cheng, J.; Lu, H." Controlled Ring-Opening Polymerization of NCA Using Organosilicon Reagents", provisional application, 2008.

     

    8. Cheng, J; Tong, R. "Particulate Drug Delivery", PCT International Application, 2008.

     

    7. Farokhzad, O.; Cheng, J.; Teply, B.; Langer, R.S. "System for targeted delivery of therapeutics agents", PCT international application, 2007, licensed by Bind Bioscience, Inc.

     

    6. Jon, S.; Farokhzad, O.C.; Langer, R.S.; Cheng, J.  "Coated Controlled Release Polymer Particles as Efficient Oral Delivery Vehicles for Biopharmaceuticals", PCT. International Application, 2006, licensed by Bind Bioscience, Inc.

     

    5. Bellocq, N.C.; Cheng, J; Pun, S.H.; Davis, M.E.  "Carbohydrate-Modified Polymers, Compositions and Uses Related Thereto", PCT. International Application, 2004, licensed by Insert Therapeutics, Inc.

     

    4. Cheng, J; Davis, M.E.; Khin, K.T. "Cyclodextrin-Based Polymers for Therapeutics Delivery", PCT. International Application, 7,270,808, issued in 2007, licensed by Insert Therapeutics, Inc.

     

    3. Pun, S.H.; Gonzalez, H.; Davis, M.E.; Bellocq, N.C.; Cheng, J. "Complexing agents for compositions containing inclusion complexes", US 716, 6302, issued in 2007, licensed by Insert Therapeutics, Inc.

     

    2. Pun, S.H.; Gonzalez, H.; Davis, M.E.; Bellocq, N.C.; Cheng, J. "Compositions containing inclusion complexes", PCT. International Application, 701,8609, issued, licensed by Insert Therapeutics, Inc.  

     

    1. Deming. T.J.; Cheng, J., "Transition Metal Initiators for Controlled Poly(β-peptide) Synthesis from Beta-Lactam Monomers ", 681,8732, issued in 2004. Licensed.