Cheng Research Group

Materials Science and Engineering
University of Illinois at Urbana-Champaign


[Google Schoolar]


180.Wang, H.; Song, Z.; Lao, Y.; Xu, X.; Gong, J.; Cheng, D.; Chakraborty, S.; Park, J.S.; Li, M.; Huang, D.; Yin, L.; Cheng, J.; Leong, K.W. “Nonviral Gene Editing via CRISPR/Cas9 Delivery by Membrane-Disruptive and Endosomolytic Helical Polypeptide “, PNAS, (NIH-HL109442; NIH-AI096305; NIH-GM110494; NIH-UH3 TR000505) [PDF] [SI] [Link]

179. Wang, R.; Cai, K.; Wang, H.; Yin, C.;  Cheng, J. “Caged metabolic precursor for DT-diaphorase responsive cell labeling”, Chem.Comm., 2018, 54, 4878–4881. (NIH-R21 1R21CA198684; NIH-1R01CA207584) [PDF] [Link]

178.Cai, K.; Ying, H.; Cheng, J. “Dynamic Ureas with Fast and pH-independent Hydrolytic Kinetics”, Chem. Eur. J., 2018, 24, 7345 –7348. (NSF-CHE15‐08710) [PDF] [SI] [Link]

177. Yin, Q.; Tang, L.; Cai, K.; Yang, X.; Yin, L.; Zhang, Y.; Dobrucki, L.W.; Helferich, W.G.; Fan, T.M.; Cheng, J. “Albumin as a “Trojan Horse” for Polymeric Nanoconjugates Transendothelial Transport across Tumor Vasculatures for Improved Cancer Targeting”, Biomater. Sci., 2018, 6, 1189–1200. (NIH-1R01CA207584 ; NIH-1R21CA198684) [PDF] [SI] [Link]

176. Lv, S.; Wu, Y.; Cai, K.; He, H.; Li, Y.; Lan, M.; Chen, x.; Cheng, J.; Yin, L. “High Drug Loading and Sub-Quantitative Loading Efficiency of Polymeric Micelles Driven by Donor-Receptor Coordination Interactions”, J. Am. Chem. Soc., 2018, 140, 1235–1238. [PDF][SI][Link]

175. He, H.; C,hen, Y.; Li, Y.; Song, Z.; Zhong, Y.; Zhu, R.; Cheng, J.; Yin, L. “Effective and Selective Anti-Cancer Protein Delivery via All-Function-in-One Nanocarriers Coupled with Visible Light-Responsive, Reversible Protein Engineering”, Adv. Funct. Mater., 2018, DOI: 10.1002/adfm.201706710. [PDF][SI][Link]


174. Ying, H.; Yen, J.; Wang, R.; Lai, Y.; Hu, Y.; Cheng, J. “Degradable and biocompatible hydrogels bearing a hindered urea bond”, Biomater. Sci., 2017, 5, 2398–2402. (NSF-CHE15-08710) [PDF][Link]

173. Zheng, N.; Song, Z.; Yang, J.; Liu, Y.; Li, F.; Cheng, J.; Yin, L. “Manipulating the membrane penetration mechanism of helical polypeptides via aromatic modification for efficient gene delivery”, Acta Biomaterialia., 2017, 58, 146–157. (NSF-CHE1153122; NIH-1DP2OD007246; NIH-1R21EB013379) [PDF][SI][Link]

172. Zheng, N.; Song, Z.; Liu, Y.; Yin, L.; Cheng, J. “Gene delivery into isolated Arabidopsis thaliana protoplasts and intact leaves using cationic, α-helical polypeptide”, Front. Chem. Sci. Eng.,  2017, 11, 521–528. (NSF-CHE115312; NIH-1DP2OD007246; NIH-1R21EB013379) [PDF] [Link]

171. Xiong, M.; Bao, Y.; Xu, X.; Wang, H.; Han, Z.; Wang, Z.; Liu, Y.; Huang, S.; Song, Z; Chen, J.; Peek, R.M. Jr., Yin, L.; Chen, L.; Cheng, J. “Selective Killing of Helicobacter pylori with pH-Responsive Helix-Coil Conformation Transitionable Antimicrobial Polypeptides”,  [PDF][SI][Link]

170. Song, Z.; Han, Z.; Lv, S.; Chen, C.; Chen, L.; Lin, Y.; Cheng, J. “Synthetic polypeptides: from polymer design to supramolecular assembly and biomedical application”, Chem. Soc. Rev., 2017, 46, 6570-6599. (NSF-CHE1308485) [PDF] [Link]

169. Ren, Y.; Baumgartner, R.; Fu, H.; Schoot, P.V.D.; Cheng, J.; Lin, Y. “Revisiting the Helical Cooperativity of Synthetic Polypeptides in Solution”, Biomacromolecules, 2017, 18, 2324-2332. (NSF-DMR1150742; NSF-CHE1410581; NSF-CHE1308485) [PDF] [SI] [Link]

168. Bao, Y.; Wu, X.; Chen, J.; Hu, X.; Zeng, F.; Cheng, J.; Jin, H. Lin, X.; Chen, L. “Brd4 modulates the innate immune response through Mnk2-eIF4E pathway-dependent translational control of IκBα”,  PNAS, 2017, 114, 3993-4001. [PDF] [SI] [Link]

167. Xia, H.; Fu, H.; Zhang, Y.; Shih, K.; Ren, Y.; Anuganti, M.; Nieh, M; Cheng, J.; Lin, Y. “Supramolecular Assembly of Comb-like Macromolecules Induced by Chemical Reactions that Modulate the Macromolecular Interactions in-situ”, J. Am. Chem. Soc., 2017, 139, 11106-11116. (NSF-DMR1150742; NSF-CHE1410581; NSF-CHE1308485) [PDF] [SI] [Link]

166. Xiong, M.; Han, Z.; Song, Z.; Yu, J.; Ying, H.; Yin, L; Cheng, J. “Bacteria-Assisted Activation of Antimicrobial Polypeptides via Random Coil-to-Helix Transition”, Angew. Chem. Int. Ed., 2017, 56, 10826 –10829. (NSF-CHE1153122; NIH-1DP2OD007246; NIH-1R21EB013379) [PDF] [SI] [Link]

165. Chen, J.; Ding, J.; Wang, Y.; Cheng, J.; Ji, S.; Zhuang, X.; Chen, X. “Sequentially Responsive Shell-Stacked Nanoparticles for Deep Penetration into Solid Tumors”, Advanced Materials, 2017, 29DOI: 10.1002/adma.201701170. [PDF] [SI] [Link]

164. Baumgartner, R.; Kuai, D.; Cheng, J. “Synthesis of controlled, high-molecular weight poly(L-glutamic acid) brush polymers”, Biomate. Sci., 2017, 5, 1836–1844. (NSF-DMR1309525; NIH-1R21AI117080) [PDF] [SI] [Link]

163. Ren, Y.; Fu, H.; Baumgartner, R.; Zhang, Y.; Cheng, J.; Lin, Y. “Folding Cooperativity of Synthetic Polypeptides with or without “Tertiary” Interactions”, ACS Macro Letter, 2017, 6, 733-737. (NSF-CHE1308485) [PDF] [SI] [Link]

162. Song, Z.; Mansbach, R.A.; He, H.; Shik, K.C.; Baumgartner, R.; Zheng, N.; Ba, X.; Huang, Y.; Mani, D.; Nieh, M.P.; Ferguson, A.L.; Yin, L.; Cheng, J. “Modulation of Polypeptide Conformation through Donor-Acceptor Transformation of Side-Chain Hydrogen Bonding Ligands”, Nature Commun., 2017, 8, 92. (NSF-CHE1308485; NSF-CBET1510468) [PDF] [SI] [Link]

161. Wang, H.; Wang, R.; Cai, K.; He, H.; Liu, Y.; Yen, J.; Wang, Z.; Xu, M.; Sun, Y.; Zhou, X.; Yin, Q.; Tang, L.; Dobrucka, I.; Dobrucki, L.; Chaney, E.; Boppart, S.; Fan, T.; Lezmi, S.; Chen, X.; Yin, L.; Cheng, J. “Selective In Vivo Cell Labeling Mediated Cancer Targeting”, Nature Chemical Biology, 2017, 13, 415-424. (NIH-1DP2OD007246; NSF-DMR1309525) [PDF] [SI] [Link]

160. Baumgartner, R., Fu, H.; Song, Z.; Lin, Y.; Cheng, J. “Cooperative polymerization of α-helices induced by macromolecular architecture”, Nature Chemistry, 2017, 9, 614–622. (NSF-CHE1308485; NSF-CHE1508710) [PDF] [SI] [Link]

159. Lee, M.W.; Han, M.; Bossa, G.W.; Snell, C.; Song, Z.; Tang, T.; Yin, L.; Cheng, J.; May, S.; Luijten, E.; Wong, GC.L. “Interactions between Membranes and “Metaphilic” Polypeptide Architectures with Diverse Side-Chain Populations”, ACS Nano, 2017, 11, 2858-2871. (NSF-DMR1309525; NIH-1R21AI117080) [PDF] [SI] [Link]

158. Lv, S.; Tang, Z.; Song, W.; Zhang, D.; Li, m.; Liu, H.; Cheng, J.; Zhong, W.; Chen, X. “Inhibiting Solid Tumor Growth In Vivo by Non-Tumor-Penetrating Nanomedicine”, Small, 2017, 13DOI: 10.1002/smll.201600954 [PDF] [SI] [Link]

157. Tian, J.; Rodgers, Z.; Min, Y.; Wan, X.; Qiu, H.; Mi, Y.; Tian, X.; Wagner, K.T.; Caster, J.M.; Qi, Y.; Roche, K.; Zhang, T.; Cheng, J.; Wang, A.Z. “Nanoparticle delivery of chemotherapy combination regimen improves the therapeutic efficacy in mouse models of lung cancer”, Nanomedicine: Nanotechnology, Biology, and Medicine, 2017, 13, 1301-1307. [PDF][SI] [Link]

156. Cai, K.; Wang, A.Z.; Yin, L.; Cheng, J. “Bio-Nano Interface: The Impact of Biological Environment on Nanomaterials and Their Delivery Properties”, J. Controlled Release, 2017, 263, 211-222. (NSF-DMR1309525; NSF-CHE1508710) [PDF] [Link]

155. Lv, S.; Wu, Y.; Dang, J.; Tang, Z.; Song, Z.; Ma, S.; Wang, X.; Chen, X.; Cheng, J.; Yin, L. “Investigation on the controlled synthesis and post-modification of poly-[(N-2-hydroxyethyl)-aspartamide]-based polymers”, Polym. Chem., 2017, 8, 1872-1877. [PDF] [SI] [Link]


154. Song, Z.; Zhang, R.; Lu, H.; Gabrielson, N.P.; Yin, L.; Ponnusamy, E.; Cheng, J. “Synthesis and Biomedical Applications of Polyamino Acids”, Materials Matters, 2016, 8, 78-84. (NSF-CHE 1153122; NIH-1DP2OD007246-01; NIH-1R21EB013379-01) [Link]

153. Yin, Q.; Tang, L.; Cai, K.; Tong, R.; Sternberg, R.; Yang, X.; Dobrucki, L.W.; Borst, L.B.; Kamstock, D.; Song, Z.; Helferich, W.G.; Cheng, J.; Fan, T.M. “Pamidronate Functionalized Nanoconjugates for Targeted Therapy of Focal Skeletal Malignant Osteolysis”, PNAS, 2016, 113, 4601-4609. (NIH-1DP2OD007246; NSF-DMR1309525) [PDF] [SI] [Link]

152. Wang, R.; Zhang, J.; Yin, Q.; Xu, Y.; Cheng, J.; Tong, R. “Controlled Ring-Opening Polymerization of O-Carboxyanhydrides Using β-Diiminate Zinc Catalyst”, Angew. Chem. Int. Ed., 2016, 55, 13010-13014. (NSF-CHE1308485) [PDF] [SI] [Link]

151. Wang, H.; Gauthier, M.; Kelly, J. R.; Miller, R.J.; Xu, M.; O’Brien, W.D.; Cheng, J. “Targeted Ultrasound Assisted Cancer-Selective Chemical Labeling and Subsequent Cancer Imaging via Click Chemistry”, Angew. Chem. Int. Ed., 2016, 55, 5452-5456. (NIH-1DP2OD007246; NSF-DMR1309525; NIH-R37EB002641) [PDF] [SI] [Link]

150. Wang, J.; Yuan, L.; Wang, Z.; Rahman, Md.A.; Huang, Y.; Zhu, T.; Wang, R.; Cheng, J.; Wang, C.; Chu, F.; Tang, C. “Photoinduced Metal-Free Atom Transfer Radical Polymerization of Biomass-Based Monomers”, Macromolecules, 2016, 49, 7709-7717. (NSF-DMR1252611) [PDF] [SI] [Link]

149. Zheng, N.; Liu, Y.; Cheng, J. “Gene Delivery Method Using Photo-Responsive Poly(b-Amino Ester)”, Non-Viral Gene Delivery Vectors, 2016, 259-267. [Link]

148. Yin, L.; Zheng, N., Cheng, J. “Highly Efficient siRNA Delivery Mediated by Cationic Helical Polypeptides and Polypeptide-Based Nanosystems”, siRNA Delivery Methods, 2016, 37-47. [Link]

147. Baumgartner, R.; Ryba, K.; Song, Z.; Wang, R.; Harris, K.; Katz, J.S.; Cheng, J.” A delayed curing ROMP based thermosetting resin”, Polym. Chem., 2016, 7, 5093-5098. (Dow Chemical Company) [PDF][SI] [Link]

146. Xing, H.; Xu, W.; Hwang, K.; Wu, P.; Yin, Q.; Li, Z.; Cheng, J.; Lu, Y. “The Effects of Spacer Length and Composition on Aptamer-Mediated Cell-Specific Targeting with Nanoscale PEGylated Liposomal Doxorubicin”, Chem.Bio.Chem., 2016, 17, 1111-1117. [PDF][SI] [Link]

145. Wang, H.; Tang, L.; Liu, Y.; Dobrucki, I.T.; Dobrucki, L.W.; Yin, L.; Cheng, J.” In VivoTargeting of Metabolically Labeled Cancers with Ultra-Small Silica Nanoconjugates”, Theranostics, 2016, 6, 1467-1476. (NIH-1DP2OD007246-01; NSF-DMR1309525; PMC4924513)[PDF][SI] [Link]

144. Song, Z.; Huang, Y.; Prasad, V.; Baumgartner, R.; Zhang, S.; Harris, K.; Katz, J.S.; Cheng, J. “Preparation of Surfactant-Resistant Polymersomes with Ultrathick Membranes through RAFT Dispersion Polymerization”, ACS Applied Materials & Interfaces, 2016, 8, 17033-17037. (Dow Chemical Company) [PDF] [SI] [Link]

143. Bai, Y.; Nguyen, L.T.; Song, Z.; Peng, S.; Lee, J.; Zheng, N.; Kapoor, I.; Hagler, L.D.; Cai, K.; Cheng, J.; Chan, H.Y.; Zimmerman, S.C. “Integrating Display and Delivery Functionality with a Cell Penetrating Peptide Mimic as a Scaffold for Intracellular Multivalent Multi-targeting”, J. Am. Chem. Soc., 2016, 138, 9498-9507. (NSF-CHE1153122) [PDF][SI] [Link]

142. Zhang, Y.; Ying, H.; Hart, K.R.; Wu, Y.; Hsu, A.J.; Coppola, A.M.; Kim, T.A.; Yang, K.; Sottos, N.R.; White, S.R.; Cheng, J. “Malleable and Recyclable Poly(urea-urethane) Thermoset Bearing Hindered Urea Bonds”, Advanced Materials, 2016, 28, 7646-7651. (NSF-CHE1508710) [PDF] [SI] [Link]

141. Azzi, J.; Yin, Q.; Uehara, M.; Ohori, S.; Tang, L.; Cai, K.; Ichimura, T.; McGrath, M.; Maarouf, M.; Kefaloyianni, E.; Loughhead, S.; Petr, J.; Sun, Q.; Kwon, M.; Tullius, M.; Andrian, U.; Cheng, J.; Abdi, R. “Targeted delivery of immunomodulators to lymph nodes”, Cell Reports, 2016, 15, 1202-1213. (NIH-1DP2OD007246; NSF-CHE1308485) [PDF] [SI] [Link]

140. Ying, H.; Cheng, J. “One-step Construction of Aminosquaraine Backbone”, Dyes and pigments, 2016, 131, 264-267. (NSF-CHE1508710) [PDF][SI][Link]

139. He, H.;Zheng, N.; Song, Z.; Kim, K.H.; Yao, C.; Zhang, R.; Zhang, C.; Huang, Y.; Uckun, F.M.; Cheng, J.; Zhang, Y.; Yin, L. “Suppression of Hepatic Inflammation via Systemic siRNA Delivery by Membrane-Disruptive and Endosomolytic Helical Polypeptide Hybrid Nanoparticles”, ACS NANO, 2016, 10, 1859-1870. ( NSF-CHE1508710) [PDF] [SI] [Link]

138. Li, Y.; Bai, Y.; Zheng, N.; Liu, Y.; Vincil, G.A.; Pedretti, B.J.; Cheng, J.; Zimmerman, S. “Crosslinked Dendronized Polyols as a General Approach to Brighter and More Stable Fluorophores”, Chem. Commun., 2016, 52, 3781-3784. [PDF] [SI] [Link]

137. Yen, J.; Ying, H.; Wang, H.; Yin, L.; Uckun, F.; Cheng, J. “CD44 Mediated Non-Viral Gene Delivery into Human Embryonic Stem Cells via Hyaluronic Acid Coated Nanoparticles”, ACS Biomater. Sci. Eng., 2016, 2, 326-335. (NIH-1DP2OD007246; NIH-1R21EB013379; NSF-CHE1153122) [PDF] [Link]

136. Kang, S.; Murphy, R.; Hwang, S.; Lee, S.; Harburg, D.; Krueger, N.; Shin, J.; Gamble, P.; Cheng, H.; Yu, S.; Liu, Z.; McCall, J.; Stephen, M.; Ying, H.; Kim, J.; Park, G.; Webb, R.; Lee, C.; Chung, S.; Wie, D.; Gujar, A.; Cheng, J.; Huang, Y.; Lee, S.; Braun, P.; Ray, W.; Rogers, J.A. ” Bioresorbable Silicon Electronic Sensors for the Brain”, Nature, 2016, 530, 71-76. [PDF][SI] [Link]


135. Cheng, J.; Pun, S.H. “Polymeric biomaterials for cancer nanotechnology”, Biomater. Sci., 2015, 3, 891-893. [PDF][Link]

134. Xiong, M.; Lee, M.W.; Mansbach, R.A.; Song, Z.; Bao, Y.; Jr. Peek, R. M.; Yao, C.; Chen, L.; Ferguson, A.L.; Wong, GC.L.; Cheng, J. “Helical Antimicrobial Polypeptides with Radial Amphiphilicity”, PNAS, 2015, 112, 13155-13160. [PDF] [SI] [Link]

133. Cai, K.; He, X.; Song, Z.; Yin, Q.; Zhang, Y.; Uckun, F.M.; Jiang, C.; Cheng, J. “Dimeric Drug Polymeric Nanoparticles with Exceptionally High Drug Loading and Quantitative Loading Efficiency”, J. Am. Chem. Soc., 2015, 137, 3458-3461. (NIH-1DP2OD007246-01; NIH-1R21CA152627;  NSF-DMR0748834; NSF-DMR1309525) [PDF] [SI] [Link]

132. Tang, L.; Yin, Q.; Xu, Y.; Zhou, Q.; Cai, K.; Yen, J.; Dobrucki, L.W.; Cheng, J. “Bioorthogonal Oxime Ligation Mediated in Vivo Cancer Targeting”, Chemical Science, 2015, 6, 2182-2186. (NIH-1DP2OD007246-01; NSF-DMR13-09525; PMC4486360) [PDF][SI][Link]

131. Wu, X.; He, C.; Wu, Y.; Chen, X.; Cheng, J. “Nanogel-Incorporated Physical and Chemical Hybrid Gels for Highly Effective Chemo-Protein Combination Therapy”, Adv. Funct. Mater., 2015, 25, 6744–6755. [PDF] [SI] [Link]

130. Priftis, D.; Leon, L.; Song, Z.; Perry, S.L.; Margossian, K.O.; Tropnikova, A.; Cheng, J.; Tirrell, M. “Self-Assembly of Alpha-Helical Polypeptides Driven by Complex Coacervation”, Angew. Chem. Int. Ed., 2015, 54, 11128-11132. (NSF-CHE1153122) [PDF] [SI] [Link]

129. Gauthier, M.; Yin, Q.; Cheng, J.; O’Brien W.D. “Design of Albumin-Coated Microbubbles Loaded With Polylactide Nanoparticles”, J. Ultrasound Med., 2015, 34, 1363-1372. (NIH-R37EB002641; NIH-1DP2OD007246) [PDF] [Link]

128. Lee, J.S.; Deng, X.; Han, P.; Cheng, J. “Dual Stimuli-Responsive Poly(beta-amino ester) Nanoparticles for On-Demand Burst Release”, Macromol. Biosci., 2015, 15, 1314-1322. (NIH-1DP2OD007246-01) [PDF] [SI] [Link]

127. Yin, Q.; Yin, L.; Wang, H.; Cheng, J. “Synthesis and biomedical applications of functional poly(alpha-hydroxy acids) via ring-opening polymerization of O-carboxyanhydrides”, Acc. Chem. Res., 2015, 48, 1777-1787. (NSF-CHE1308485; NIH-1DP2OD007246-01) [PDF] [Link]

126. Uckun, F.M.; Mitchell, L.G.; Qazi, S.; Myers, D.E.; Ma, H.; Zheng, N.; Song, Z.; Liu, Y.; Cheng, J. “Development of Polypeptide-Based Nanoparticles for Non-Viral Delivery of CD22 RNA Trans-splicing Molecule as a New Precision Medicine Candidate Against B-lineage ALL”, EBioMedicine, 2015, 2, 649-659. (NIH-1DP2OD007246-01; NSF-CHE1308485; PMC4534679) [PDF] [Link]

125. Song, Z.; Kim, H.; Ba, X.; Baumgartner, R.; Lee, J.; Tang, H.; Leal, C.; Cheng, J. “Polypeptide Vesicles with Densely Packed Multilayer Membranes”, Soft Matter, 2015, 11, 4091-4098. (Dow Chemical Company; NSF-CHE1308485) [PDF] [SI] [Link]

124. Uckun, F.M.; Qazi, S.; Cheng, J.; Myers, D.E. “Liposomal Nanoparticles of a Spleen Tyrosine Kinase P-site Inhibitor Amplify the Potency of Low Dose Total Body Irradiation Against Aggressive B-precursor Leukemia and Yield Superior Survival Outcomes in Mice EBioMedicine”, EBioMedicine, 2015, 2, 554-562. (NIH-1DP2OD007246-01; PMC4535154) [PDF][SI] [Link]

123. Torabi, S.F.; Wu, P.; McGhee, C.E.; Chen, L.; Hwang, K.; Zheng, N.; Cheng, J.; Lu, Y. “In vitro selection of a sodium-specific DNAzyme and its application in intracellular sensing”, PNAS, 2015, 112, 5903-5908. (PMC4434688; NIH-ES016865) [PDF][SI] [Link]

122. Tang, L.; Tong, R.; Coyle, V.J.; Yin, Q.; Pondenis, H.; Borst, L.B.; Cheng, J.; Fan, T.M. “Targeting Tumor Vasculature with Aptamer Functionalized Doxorubicin-Polylactide Nanoconjugates for Enhanced Cancer Therapy”, ACS Nano, 2015, 9, 5072-5081. (NIH-1DP2OD007246-01; NIH-1R21CA152627) [PDF] [SI] [Link].

121. Uckun, F.M.; Qazi, S.; Cheng, J. “Targeting leukemic stem cells with multifunctional bioactive polypeptide nanoparticles”, Future Oncology, 2015, 11, 1149-1152. (NIH-1DP2OD007246-01) [PDF] [Link]

120. Baumgartner, R.; Song, Z.; Zhang, Y.; Cheng, J. “Functional Polyesters Derived from Alternating Copolymerization of Norbornene Anhydride and Epoxides”, Polym. Chem., 2015, 6, 3586-3590. (Dow Chemical Compay) [PDF] [SI] [Link]

119. Zhang, Y.; Yin, Q.; Yen, J.; Li, J.; Ying, H.; Wang, H.; Hua, Y.; Chaney, E.; Boppart, S.; Cheng, J. “Non-Invasive, Real-Time Reporting Drug Release In Vitro and In Vivo“, Chem.Commun., 2015, 51, 6948-6951. (NIH-1DP2OD007246-01; NIH-R25CA154015A) [PDF] [SI] [Link]

118. Andrade, B.; Song, Z.; Li, J.; Zimmerman, S.; Cheng, J.; Moore, J.S.; Harris, K.; Katz, J. “New Frontiers for Encapsulation in the Chemical Industry”, ACS Appl. Mater. Interfaces, 2015, 7, 6359−6368. (Dow Chemical Company) [PDF] [Link]

117. Wang, H.C.; Zhang, Y.; Possanza, C.; Zimmerman, S.; Cheng, J.; Moore, J.; Harris, K.; Katz, J. “Trigger Chemistries for Better Industrial Formulations”, ACS Appl. Mater. Interfaces, 2015, 7, 6369-6382. (Dow Chemical Company) [PDF] [Link]

116. Wang, H.; Xu, M.; Xiong, M.; Cheng, J. “Reduction-Responsive Dithiomaleimide-Based Nanomedicine with High Drug Loading and FRET-Indicated Drug Release “, Chem. Commun., 2015, 51, 4807-4810. (NSF-DMR1309525; NIH-1DP2OD007246-01) [PDF] [SI] [Link]

115. Zheng, N.; Song, Z.; Liu, Y.; Zhang, R.; Zhang, R.; Yao, C.; Uckun, F.M.; Yin, L.; Cheng, J. “Redox-responsive, reversibly-crosslinked thiolated cationic helical polypeptides for efficient siRNA encapsulation and delivery”, J. Controlled Release, 2015, 205, 231-239. (NSF-CHE1153122; NIH-1DP2OD007246-01; NIH-1R21EB013379-01) [PDF] [Link]

114. Uckun, F.M.; Ma, H.; Cheng, J.; Myers, D.E.; Qazi, S. “CD22deltaE12 as a molecular target for RNAi therapy”, British Journal of Haematology, 2015, 169, 401-414. (NIH-1DP2OD007246-01) [PDF] [SI] [Link]

113. Cai, K.; Yen, J.; Yin, Q.; Liu, Y.; Song, Z.; Lezmi, S.; Zhang, Y.; Yang, X.; Helferich, W.G.; Cheng, J. “Redox-Responsive Self-Assembled Chain-Shattering Polymeric Therapeutics”, Biomater. Sci., 2015, 3, 1061-1065. (NSF-DMR 0748834; NSF-DMR1309525; NIH-1DP2OD007246-01; NIH-1R21CA152627) [PDF] [SI] [Link]

112. Yin, L.; Chen, Y.; Zhang, Z.; Yin, Q.; Zheng, N.; Cheng, J. “Biodegradable Micelles Capable of Mannose-Mediated Targeted Drug Delivery to Cancer Cells”, Macromol. Rapid Commun., 2015, 36, 483-489. (NSF-CHE1153122; NIH-1DP2OD007246; NIH-1R21EB013379) [PDF] [SI] [Link]

111. Ma, L.; Baumgartner, R.; Zhang, Y.; Song, Z.; Cai, K.; Cheng, J. “UV-Responsive Degradable Polymers Derived from 1-(4-Aminophenyl) ethane-1, 2-diol”, JOURNAL OF POLYMER SCIENCE, PART A: POLYMER CHEMISTRY, 2015, 53, 1161-1168. (Dow Chemical Company) [PDF] [SI] [Link]

110. Zhang, R.; Song, Z.; Yin, L.; Lu, H.; Gabrielson, N.P.; Cheng, J. “Ionic α-Helical Polypeptides towards Non-Viral Gene Delivery”, WIREs Nanomedicine & Nanobiotechnology, 2015, 7, 98-110. (NSF-CHE1153122; NIH-1DP2OD007246-01; NIH-1R21EB013379-01) [PDF] [Link]


109. Qu, Q.; Dong, L.; Louis, K.R.; Li, X.; Yang, H.; Sun, Q.; Crandall, S.R.; Tsang, S.; Zhou, J.; Cox, C.L.; Cheng, J.; Wang, F. “High-efficiency motor neuron differentiation from human pluripotent stem cells and the function of Islet-1”, Nature Communications, 2014, 5, 3449. [PDF][SI] [Link]

108. Ying, H.; Zhang, Y.; Cheng, J. “Dynamic urea bond for the design of reversible and self-healing polymers”, Nature Communications, 2014, 5, 3218. (NSF-CHE1153122; NIH-1DP2OD007246-01) [PDF][SI][Link]

107. Tang, L.; Yang, X.; Yin, Q.; Cai, K.; Wang, H.; Chaudhury, I.; Yao, C.; Zhou, Q.; Kwon, M.; Hartman, J.A.; Dobrucki, I.T.; Dobrucki, L.W.; Borst, L.B.; Lezmi, S.; Helferich, W.G.; Ferguson, A.L.; Fan, T.M.; Cheng, J. “Investigating the optimal size of anticancer nanomedicine”, PNAS, 2014, 111, 15344-15349. (NIH-1DP2OD007246-01; NIH-1R21CA152627; PMC4217425) [PDF][SI] [Link]

106. Ying, H.; Cheng, J. “Hydrolysable Polyureas Bearing Hindered Urea Bonds”, J. Am. Chem. Soc., 2014, 136, 16974-16977. (NSF-CHE1153122; NIH-1DP2OD007246-01) [PDF][SI][Link]

105. Uckun, F.M.; Qazi, S.; Ma, H.; Yin, L.; Cheng, J. “A rationally designed nanoparticle for RNA interference therapy in B-lineage lymphoid malignancies”, EBioMedicine, 2014, 1, 141-155. (NIH-1DP2OD007246-01; PMC4292938) [PDF][SI] [Link]

104. Yin, L.; Huang, X.; Xu, H.; Zhang, Y.; Lam, J.; Cheng, J.; Rogers, J.A. ” Materials, Designs, and Operational Characteristics for Fully Biodegradable Primary Batteries”, Advanced Materials, 2014, 26, 3879-3884. [PDF][SI] [Link]

103. Yen, J.; Yin, L.; Cheng, J. “Enhanced Non-Viral Gene Delivery to Human Embryonic Stem Cells via Small Molecule-Mediated Transient Alteration of Cell Structure”, J. Mater. Chem. B., 2014, 2, 8098-8105. (NIH-1DP2OD007246-01; NIH-1R21EB013379-01; NSF-CHE1153122) [PDF][SI] [Link]

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30. Tong, R.; Cheng, J. “Ring-Opening Polymerization Mediated-Controlled Formulation of Polylactide Nanoparticles”, J. Am. Chem. Soc., 2009, 131, 4744-4754. (NSF-DMR0748834) [PDF] [SI] [Link]

29. Tong, R.; Christian, D.A.; Tang, L.; Cabral, H.; Baker, J.R. Jr.; Kataoka, K.; Discher, D.; Cheng, J. “Nanopolymeric Therapeutics”, MRS Bulletin, 2009, 34, 422-431. (NSF-DMR0748834) [PDF] [Link]

28. Tong, R.; Tang, L.; Yala, L.; Cheng, J. “Controlled formulation of doxorubicin-polylactide nanoconjugates for cancer drug delivery”, IEEE. Eng Med Biol Soc. 2009, 1, 2400-2402. (NSF-DMR0748834) [PDF] [Link]

27. Yigit, M.V.; Mishra, A.; Tong, R.; Cheng, J.; Wong, G.C.L.; Lu, Y. “Inorganic mercury detection and controlled release of chelating agents from ion-responsive PEG-liposomes”, Chem. Biol., 2009, 16, 937-942. (NSF-CTS0120978; NSF-DMR0117792; DE-FG02-08ER64568) [PDF] [SI] [Link]


26. Lu, H.; Cheng, J. “N-Trimethylsilyl Amines for Controlled Ring-Opening Polymerization of Amino Acid N-Carboxyanhydrides and Facile End Group Functionalization of Polypeptides”, J. Am. Chem. Soc., 2008, 13012562–12563. (NSF-CHE0809420) [PDF][SI][Link]

25. Tong, R.; Cheng, J. “Paclitaxel-Initiated, Controlled Polymerization of Lactide for the Formulation of Polymeric Nanoparticulate Delivery Vehicles”, Angew. Chem. Int. Ed., 2008, 47, 4830-4834. (NSF-DMR07-48834) [PDF] [SI] [Link]

24. Lee, J.S.; Cheng, J.; Kim, K.Y. “Next Generation Nanosolutions for Cancer Treatment and Diagnosis”, Cancer and Chemotherapy Review, 2008, 3, 144-151.[PDF] [Link]

23. Teply, B.A.; Tong, R.; Jeong, S.Y.; Luther, G.; Sherifi, I.; Yim, C.H.; Khademhosseini, A.; Farokhzad, O.C.; Langer, R.; Cheng, J. “The Use of Charge-Coupled Polymeric Microparticles and Micromagnets for Modulation the Bioavailability of Orally Delivered Macromolecules”, Biomaterials, 2008, 29, 1216-1223. (PMC2268909; NIH-MS39924) [PDF] [Link]


22. Lu, H.; Cheng, J. “Hexamethyldisilazane-Mediated Controlled Polymerization of α-Amino Acid-NCarboxyanhydrides”, J. Am. Chem. Soc., 2007, 129, 14114-14115[PDF] [SI] [Link]

21. Tong, R.; Cheng, J. “Anticancer Polymeric Nanomedicines”, Polymer Reviews, 2007, 47, 345-381. [PDF] [Link]

20. Karp, J.M.; Yeh, J.; Eng, G.; Fukuda, J.; Blumling, J.; Suh, K.Y.; Cheng, J.; Mahdavi, A.; Borenstein, J.; Langer, R.; Khademhosseini, A. “Controlling size, shape and homogeneity of embryoid bodies using poly(ethylene glycol) microwells”, Lab Chip, 2007, 7, 786-794. [PDF] [Link]

19. Cheng, J.; Teply, B.; Sherifi, I.; Sung, J.; Luther, G.; Gu, F.X.; Levy-Nissenbaum, E.; Langer, R.S.; Farokhzad, O.C. “Formulation of Functionalized PLGA-PEG Nanoparticles for In Vivo Targeted Drug Delivery”, Biomaterials, 2007, 28, 869-876. (PMC2925222; NIH-MS14538) [PDF][Link]


18. Farokhzad, O.C.; Cheng, J.; Teply, B.A.; Sherifi, I.; Jon, S.; Kantoff, P.W.; Richie, J.P.; Langer, R. “Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo”, 

17. Cheng, J.; Zeidan, R.; Mishra, M.; Liu, A.; Pun, S.H.; Kulkarni, R.P.; Jensen, G.S.; Bellocq, N.; Davis, M.E. “Structure-Function Correlation of Chloroquine and Analogues as Transgene Expression Enhancers in Non-Viral Gene Delivery”, J. Med. Chem., 2006, 49, 6522-6531. [PDF] [SI] [Link]

16. Schluep, T.; Hwang, J.; Cheng, J.; Heidel, J.D.; Derek, W.; Bartlett, D.W.; Davis, M.E. “Preclinical Efficacy of the Camptothecin-Polymer Conjugate IT-101 in Multiple Cancer Models”, Clinical Cancer Research, 2006, 12, 1606-1614. [PDF] [Link]

15. Cheng, J.; Teply, B.; Yim, C.; Jeong, S.Y.; Sherifi, I.; Jon, S.; Khademhosseini, A.; Farokhzad, O.C.; Langer, R. “Magnetically Responsive Polymeric Microparticles for Oral Delivery of Protein Drugs”, Pharmaceutical Research, 2006, 23, 557-564. [PDF] [Link]

14. Fukuda, J.; Khademhosseini, A.; Yeh, J.; Eng, G.; Cheng, J.; Farokhzad, O.C.; Langer, R. “Micropatterned cell co-cultures using layer-by-layer deposition of extracellular matrix components”, Biomaterials, 2006, 27,1479-86. [PDF] [Link]

13. Schluep, T.; Cheng, J.; Khin, K.T.; Davis, M.E. “Pharmacokinetics and biodistribution of the camptothecin-polymer conjugate IT-101 in rats and tumor bearing mice”, Cancer Chemotherapy and Pharmacology, 2006, 57, 654-662. [PDF] [Link]


12. Cheng, J.; Yim, C.H.; Teply, B.A.; Ho, D.; Farokhzad, O.C.; Langer, R.S. “Magnetite-PLGA Microparticles for Oral Delivery of Insulin”, Mater. Res. Soc. Symp. Proc., 2005, 873, 581-586. (DuPont-MIT Alliance) [PDF] [Link]

11. Cheng, J.; Pun, S.H. “Nanotechnology in Drug Delivery”, In “An Executive’s Guide to Nanotechnology”, Editor: Lynn Foster, Prentice Hall, 2005.

10. Farokhzad, O.; Khademhosseini, A.; Jon, S.; Hermmann, A.; Cheng, J.; Chin, C.; Kiselyuk, A.; Eng, G.; Langer, R.S. “Microfluidic System for Studying the Interaction of Nanoparticles and Microparticles with Cells”, Analytical Chemistry, 2005, 77, 5453-5459.  [PDF] [Link]

9. Pun, S.H.; Tack, F.; Bellocq, N.C.; Cheng, J.; Grubbs, B.H.; Jensen, G.S.; Davis, M.E.; Brewster, M.; Janicot, M.; Janssens, B.; Floren, W.; Bakker, A.” Targeted delivery of RNA-cleaving DNA enzyme (DNAzyme) to tumor tissue by transferrin-modified, cyclodextrin-based particles”, Cancer biology & therapy ,2004, 3, 641-650. [PDF] [Link]

8. Cheng, J.; Khin, K.T.; Davis, M.E. “Antitumor Activity of (β-Cyclodextrin Polymer-Camptothecin Conjugates”, Molecular Pharmaceutics, 2004, 1, 183-193. [PDF] [Link]

7. Cheng, J.; Khin, K.T.; Jensen, G.S.; Liu, A.; Davis, M.E. “Synthesis of Linear, β-Cyclodextrin-Based Polymers and Their Camptothecin Conjugates”, Bioconjugate Chemistry, 2003, 14, 1007-1017. [PDF] [Link]

6. Cheng, J.; Deming, T.J., “Controlled Polymerization of Beta-lactams Using Metal-Amido Complexes: Synthesis of Block Copoly(β-peptides)”, J. Am. Chem. Soc., 2001, 123, 9457-9458. [PDF] [SI] [Link]

5. Cheng, J.; Deming, T.J. “Synthesis and Conformational Analysis of Optically Active Poly(β-peptides)”, Macromolecules, 2001, 34, 5169-5174. [PDF] [Link]

4. Cheng, J.; Ziller, J.W.; Deming, T.J. “Synthesis of Optically Active β-Amino Acid N-Carboxyanhydrides”, Organic Letters, 2000, 2, 1943-1946. [PDF] [SI] [Link]

3. Cheng, J.; Deming, T.J. “Screening of Optically Active Nickel Initiators for Enantioasymmetric Polymerization of α-Benzyl Glutamate-N-Carboxyanhydride”, Macromolecules, 1999, 32, 4745-4747. [PDF] [SI] [Link]

2. Smith, G.V.; Cheng, J.; Song, R. “New Enantioselective Heterogeneous Catalysts”, Catalysts Letters, 1997, 45, 73-78. [PDF] [Link]

1. Smith, G.V.; Cheng, J.; Song, R. “Enantioselective Hydrogenation of Prochiral C=C Bonds over Nobel Metal Catalysts Supported by β-Cyclodextrin Polymer”, Catalysts of Organic Reactions, 1996, 479-484. [PDF]


33. Cheng, J.; Ying, H. “Cyclic dynamic polyureas for polymeric urea processing”, US Patent App. 15/547,525, 2018.

32. Cheng, J.; Tong, R. “Particulate drug delivery methods”, US Patent 9,789,195, 2017.

31. Cheng, J.; Yin, L. “Nanoparticle mediated delivery of siRNA”, US Patent 9,617,544, 2017.

30. Cheng, J.; Zhang, Y. “Trigger-responsive chain-shattering polymers”, US Patent 9,593,197, 2017.

29. Cheng, J.; Gabrielson, N.; Yin, L. “Multiplexed supramolecular assemblies for non-viral delivery of genetic material”, US Patent 9,572,895, 2017.

28. Cheng, J.; Lu, H. “Stable helical ionic polypeptides”, US Patent 9,243,040, 2016.

27. Cheng, J.; Cai, K.; Ying, H. “Dynamic Urea Bonds with Fast Hydrolytic Kinetics for Polymers”, US 62/304,964, 2016.

26. Cheng, J.; Wang, H. “Trigger-Activatable Metabolic Sugar Precursors for Cancer-Selective Labeling and Targeting”, US 62/238,326, 2015.

25. Cheng, J.; Xiong, M.; Song, Z. “Antimicrobial Alpha-Helical Cationic Polypeptides”, US 62/185,345, 2015. (TF14094)

24. Cheng, J.; Tong, R. “Nanoconjugates and Nanoconjugate Formulations”, US Patent 9,295,651, 2016.

23. Cheng, J.; Cai, K. “Trigger Responsive Drug Conjugate for High Loading Nanoencapsulates”, US 62/120,821, 2015. (TF14168)

22. Cheng, J.; Tang, L. “Silica nanoparticle agent conjugates”, US Patent 9,028,880, 2015.

21. Cheng, J.; Ying, H.; Zhang, Y. “Dynamic urea bonds for polymers”, US 62/069, 385, 2014. (TF14085)

20. Cheng, J.; Ying, H. “Hydrolysable polymers with dynamic urea bonds”, US 62/069, 384, 2014. (TF14085)

19. Cheng, J.; Yen, J. “Enhanced Non-Viral Gene Delivery to Human Embryonic Stem Cells, Provision Patent Application”, US 62/029,964, 2014. (TF14100)

18. Rogers, J.A.; Kang, S.; Hwang, S.; Cheng, J.; Zhang, Z.; Ying, H. “Transient Electronic Devices Comprising Inorganic or Hybrid Inorganic and Organic substrates and encapsulates”,US 61/811,603.

17. Cheng, J.; Ying, H. “Dynamic urea bonds for reversible and self-healing polymers”, US 61/799,144, 2013. (TF 12136)

16. Cheng, J.; Yin, L. “Supramolecular Self-Assembled Nanoparticles Mediate Oral Delivery of Therapeutic TNF-a siRNA Against Systemic Inflammation”, US 61/810,983, 2013. (TF13054)

15. Cheng, J.; Zhang, Y. “Trigger-Responsive, Degradable Polymers”, US 61/649,205; US 61/648,715, 2012. (TF11176)

14. Cheng, J.; Lu, H. “Ionic Polypeptides with Unusual Helical Stability”, Converted US 61/418,269; WO PCT/US2011/062656, 2011. (TF10060)

13. Cheng, J.; Gabrielson,N.P. “Supramolecular Assembly for Non-Viral Gene Delivery”, US 61/371,618 2010; WO PCT/US2011/046791, 2011. (TF10042).

12. Cheng, J.; Tang, L. “Preparation of Degradable Silica-Drug Conjugated Nanoparticle with Monodisperse Particle Sizes”, US 61/418,230 2010; WO PCT/US2011/062548, 2011. (TF09149).

11. Cheng, J.; Tong, R. “Particulate Drug Delivery” PRO 60/892,834, 2007; US 12/041,529 2008; WO PCT/US2008/055590, 2008. (TF06188)

10. Chung, L.W.K.; Yang, X.; Cheng, J.; Tong, R. “Small molecule mediated cancer targeting and therapy” provisional application, 2008, US Patent App. 12/995,417.

9. Cheng, J.; Lu, H.” Controlled Ring-Opening Polymerization of NCA Using Organosilicon Reagents”, provisional application, 2008.

8. Cheng, J; Tong, R. “Particulate Drug Delivery”, PCT International Application, 2008; US Patent App. 12/041,529.

7. Farokhzad, O.; Cheng, J.; Teply, B.; Langer, R.S. “System for targeted delivery of therapeutics agents”, PCT international application, 2007, licensed by Bind Bioscience, Inc; US Patent     8,709,483, 2014; US Patent App. 14/322,738; US Patent 8,802,153.

6. Jon, S.; Farokhzad, O.C.; Langer, R.S.; Cheng, J. “Coated Controlled Release Polymer Particles as Efficient Oral Delivery Vehicles for Biopharmaceuticals”, PCT. International Application,     2006,  licensed by Bind Bioscience, Inc.

5. Bellocq, N.C.; Cheng, J; Pun, S.H.; Davis, M.E. “Carbohydrate-Modified Polymers, Compositions and Uses Related Thereto”, PCT. International Application, 2004, licensed by Insert     Therapeutics, Inc.

4. Cheng, J; Davis, M.E.; Khin, K.T. “Cyclodextrin-Based Polymers for Therapeutics Delivery”, PCT. International Application, 7,270,808, issued in 2007, licensed by Insert Therapeutics, Inc.

3. Pun, S.H.; Gonzalez, H.; Davis, M.E.; Bellocq, N.C.; Cheng, J. “Complexing agents for compositions containing inclusion complexes”, US 716, 6302, issued in 2007, licensed by Insert Therapeutics, Inc.

2. Pun, S.H.; Gonzalez, H.; Davis, M.E.; Bellocq, N.C.; Cheng, J. “Compositions containing inclusion complexes”, PCT. International Application, 701,8609, issued, licensed by Insert Therapeutics, Inc.

1. Deming. T.J.; Cheng, J. “Transition Metal Initiators for Controlled Poly(β-peptide) Synthesis from Beta-Lactam Monomers “, US Patent 6,818,732681,8732.